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Sapienic acid sodium

Cat. No. M21218
Sapienic acid sodium Structure
Size Price Availability
5mg USD 150  USD150 4-7 Days
10mg USD 210  USD210 4-7 Days
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Quality Control & Documentation
Biological Activity

Sapienic acid sodium is a fatty acid commonly found on the skin and in mucosa. Sapienic acid sodium is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively. Sapienic acid sodium has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity.

Chemical Information
Molecular Weight 276.39
Formula C16H29NaO2
CAS Number 217477-25-3
Solubility (25°C) Ethanol 30 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chunrong Yang, et al. Fish Shellfish Immunol. Identification and expression profiles of ADAR1 gene, responsible for RNA editing, in responses to dsRNA and GCRV challenge in grass carp (Ctenopharyngodon idella)

[2] Carol L Fischer, et al. Antimicrob Agents Chemother. Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria

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