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SKI-V

Cat. No. M21034

All AbMole products are for research use only, cannot be used for human consumption.

SKI-V Structure

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Quality Control & Documentation
Biological Activity

SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.

Chemical Information
Molecular Weight 254.24
Formula C15H10O4
CAS Number 24418-86-8
Solubility (25°C) DMSO 51 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yan Zhang, et al. Int J Biol Sci. The sphingosine kinase inhibitor SKI-V suppresses cervical cancer cell growth

[2] Xu Sun, et al. Cell Death Discov. The anti-osteosarcoma cell activity by the sphingosine kinase 1 inhibitor SKI-V

[3] Huawei Jiang, et al. OMICS. Next generation sequencing analysis of miRNAs: MiR-127-3p inhibits glioblastoma proliferation and activates TGF-β signaling by targeting SKI

[4] Carmen D Schweighofer, et al. PLoS One. A two-gene signature, SKI and SLAMF1, predicts time-to-treatment in previously untreated patients with chronic lymphocytic leukemia

[5] F Tokitou, et al. J Biol Chem. Viral ski inhibits retinoblastoma protein (Rb)-mediated transcriptional repression in a dominant negative fashion

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Abmole Inhibitor Catalog




Keywords: SKI-V supplier, SPHK, inhibitors, activators

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