About 16 results found for searched term "SPHK" (0.136 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3012 | SKI II | S1P Receptor |
| SphK-I2 | ||
| SKI II is a highly selective and non ATP-competitive S1P receptor inhibitor with IC50 of 0.5 μM, while exhibits no inhibitory on other kinases including PI3K, PKCα and ERK2. | ||
| M3719 | K145 hydrochloride | SPHK |
| SphK2 inhibitor | ||
| K145 Hydrochloride is a selective, substrate competitive and oral inhibitor of SphK2, IC50 4.3 µM and Ki 6.4 µM. K145 hydrochloride has no activity against SphK1 and other protein kinases. K145 Hydrochloride induces apoptosis and has strong anti-tumor activity. | ||
| M2930 | PF-543 | SPHK |
| PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. | ||
| M4647 | Phorbol 12-myristate 13-acetate | PKC |
| PMA, TPA, 12-O-tetradecanoyl-phorbol-13-acetate; 12,13-tetradecanoyl phorbol acetate | ||
| Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and protein kinase C (PKC) activator, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM. | ||
| M8194 | SKI 5C | Others |
| SKI 5C is a selective Sphingosine Kinase 1 (SPHK1) inhibitor. | ||
| M8631 | K6PC-5 | Others |
| K6PC-5 is a potent and selective sphingosine kinase 1 (SphK1 or SK1) activator that increases keratin 1 and involucrin expression in normal human epidermal keratinocytes cultured in vitro. | ||
| M9455 | PF-543 Citrate | S1P Receptor |
| PF-543 Citrate is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. | ||
| M10599 | PF-543 HCl | SPHK |
| PF-543 HCl; PF543 hydrochloride | ||
| PF-543 hydrochloride is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. | ||
| M11262 | MHP | SPHK |
| Methyl caprooyl tyrosinate | ||
| MHP (Methyl caprooyl tyrosinate), an activator of sphingosine kinase (SPHK1), can significantly increase CAMP mRNA and protein levels. MHP (Methyl caprooyl Tyrosinate) can enhance anti-microbial defense and innate immunity. | ||
| M13355 | MP-A08 | SPHK |
| Mp-a08 is a highly selective inhibitor of ATP-competitive sphingine kinase (SPHK1) with Ki value of 6.9 μM. | ||
| M13356 | SKI-178 | SPHK |
| SKI-178 is a potent sphingosine kinase-1 (SphK1) and SphK2 inhibitor. In acute myeloid leukemia (AML) cell lines, the IC50 range is about 500 nm-1 μM. Ski-178 induces apoptosis of human acute myeloid leukemia cells in a CDK1-dependent manner. | ||
| M13395 | SK1-IN-1 | SPHK |
| Sk1-in-1 is an effective sphingosine kinase 1 (SPHK1) inhibitor with an IC50 value of 58 nM. | ||
| M13396 | SK1-I hydrochloride | SPHK |
| BML-258 hydrochloride | ||
| SK1-I hydrochloride (BML-258 hydrochloride), an analogue of sphingine, is an isozyme-specific competitive SPHK1 inhibitor with a Ki value of 10 µM. | ||
| M27913 | N,N-Dimethylsphingosine | SPHK |
| N,N-Dimethylsphingosine is a potent inhbitor of SphK (sphingosine kinase) as an endogenous metabolite of sphingosine produced in various tissues and tumor cell lines. | ||
| M29002 | SLM6031434 hydrochloride | SPHK |
| SLM6031434 hydrochloride is a highly selective sphingosine kinase 2 (SphK2) inhibitor with Kis of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 hydrochloride decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 hydrochloride has the potential for renal fibrosis research. | ||
| M38970 | Benzyl butyl phthalate | Aryl hydrocarbon Receptor |
| Benzyl butyl phthalate can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs). | ||
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