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K145 hydrochloride

Cat. No. M3719
K145 hydrochloride Structure

SphK2 inhibitor

Size Price Availability Quantity
10mg USD 105.3  USD117 In stock
50mg USD 319.5  USD355 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

K145 hydrochloride accumulates in U937 cells, suppresses the S1P level, and inhibits SphK2 by using human leukemia U937 cells in vitro studies. K145 hydrochloride exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells, and that these effects may be through the inhibition of down-stream ERK and Akt signaling pathways. K145 hydrochloride significantly inhibited the growth of U937 tumors in nude mice by both intraperitoneal and oral administration, thus demonstrating its in vivo efficacy as a potential lead anticancer agent. The antitumor activity of K145 was also confirmed in a syngeneic mouse model by implanting murine breast cancer JC cells in BALB/c mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 384.92
Formula C18H24N2O3S.HCl
CAS Number 1449240-68-9
Purity >99%
Solubility Water 90 mg/mL
DMSO 40 mg/mL
Storage at -20°C

3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]- thiazolidine-2,4-dione (K145) ameliorated dexamethasone induced hepatic gluconeogenesis through activation of Akt/FoxO1 pathway
Yanan Shi, et al. Biochem Biophys Res Commun. 2017 Nov 4;493(1):286-290. PMID: 28911865.

Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent.
Liu K, et al. PLoS One. 2013;8(2):e56471. PMID: 23437140.

Related SPHK Products

PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform.

Abmole Inhibitor Catalog 2017

Keywords: K145 hydrochloride, SphK2 inhibitor supplier, SPHK, inhibitors

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