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K145 hydrochloride

Cat. No. M3719
K145 hydrochloride Structure

SphK2 inhibitor

Size Price Availability Quantity
5mg USD 80  USD80 In stock
10mg USD 131  USD131 In stock
50mg USD 450  USD450 In stock
100mg USD 825  USD825 In stock
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Quality Control & Documentation
Biological Activity

K145 Hydrochloride is a selective, substrate competitive and oral inhibitor of SphK2, IC50 4.3 µM and Ki 6.4 µM. K145 hydrochloride has no activity against SphK1 and other protein kinases. K145 Hydrochloride induces apoptosis and has strong anti-tumor activity.

Chemical Information
Molecular Weight 384.92
Formula C18H24N2O3S.HCl
CAS Number 1449240-68-9
Solubility (25°C) Water 90 mg/mL
DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Yanan Shi, et al. Biochem Biophys Res Commun. 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]- thiazolidine-2,4-dione (K145) ameliorated dexamethasone induced hepatic gluconeogenesis through activation of Akt/FoxO1 pathway

[2] Liu K, et al. PLoS One. Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent.

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Abmole Inhibitor Catalog

Keywords: K145 hydrochloride, SphK2 inhibitor supplier, SPHK, inhibitors, activators

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