Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M29002 | SLM6031434 hydrochloride | SLM6031434 hydrochloride is a highly selective sphingosine kinase 2 (SphK2) inhibitor with Kis of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 hydrochloride decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 hydrochloride has the potential for renal fibrosis research. |
| M13356 | SKI-178 | SKI-178 is a potent sphingosine kinase-1 (SphK1) and SphK2 inhibitor. In acute myeloid leukemia (AML) cell lines, the IC50 range is about 500 nm-1 μM. Ski-178 induces apoptosis of human acute myeloid leukemia cells in a CDK1-dependent manner. |
| M13355 | MP-A08 | Mp-a08 is a highly selective inhibitor of ATP-competitive sphingine kinase (SPHK1) with Ki value of 6.9 μM. |
| M11262 | MHP | MHP (Methyl caprooyl tyrosinate), an activator of sphingosine kinase (SPHK1), can significantly increase CAMP mRNA and protein levels. MHP (Methyl caprooyl Tyrosinate) can enhance anti-microbial defense and innate immunity. |
| M10599 | PF-543 HCl | PF-543 hydrochloride is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. |
| M3719 | K145 hydrochloride | K145 Hydrochloride is a selective, substrate competitive and oral inhibitor of SphK2, IC50 4.3 µM and Ki 6.4 µM. K145 hydrochloride has no activity against SphK1 and other protein kinases. K145 Hydrochloride induces apoptosis and has strong anti-tumor activity. |
| M2930 | PF-543 | PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. |
| M27913 | N,N-Dimethylsphingosine | N,N-Dimethylsphingosine is a potent inhbitor of SphK (sphingosine kinase) as an endogenous metabolite of sphingosine produced in various tissues and tumor cell lines. |
| M21034 | SKI-V | SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity. |
| M20194 | WAY-604116 | WAY-604116 is a sphingosine kinase inhibitor |
| M20173 | WAY-358981 | WAY-358981 is a Sphingosine kinase inhibitor |
| M20047 | WAY-272077 | WAY-272077 is a haemostatic agent. |
| M13396 | SK1-I hydrochloride | SK1-I hydrochloride (BML-258 hydrochloride), an analogue of sphingine, is an isozyme-specific competitive SPHK1 inhibitor with a Ki value of 10 µM. |
| M13395 | SK1-IN-1 | Sk1-in-1 is an effective sphingosine kinase 1 (SPHK1) inhibitor with an IC50 value of 58 nM. |
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