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SPHK Sphingosine kinase

Inhibitors

Cat.No.  Name Information
M21034 SKI-V SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.
M20194 WAY-604116 WAY-604116 is a sphingosine kinase inhibitor
M20173 WAY-358981 WAY-358981 is a Sphingosine kinase inhibitor
M20047 WAY-272077 WAY-272077 is a haemostatic agent.
M13396 SK1-I hydrochloride SK1-I hydrochloride (BML-258 hydrochloride), an analogue of sphingine, is an isozyme-specific competitive SPHK1 inhibitor with a Ki value of 10 µM.
M13395 SK1-IN-1 Sk1-in-1 is an effective sphingosine kinase 1 (SPHK1) inhibitor with an IC50 value of 58 nM.
M13356 SKI-178 SKI-178 is a potent sphingosine kinase-1 (SphK1) and SphK2 inhibitor. In acute myeloid leukemia (AML) cell lines, the IC50 range is about 500 nm-1 μM. Ski-178 induces apoptosis of human acute myeloid leukemia cells in a CDK1-dependent manner.
M13355 MP-A08 Mp-a08 is a highly selective inhibitor of ATP-competitive sphingine kinase (SPHK1) with Ki value of 6.9 μM.
M11262 MHP MHP (Methyl caprooyl tyrosinate), an activator of sphingosine kinase (SPHK1), can significantly increase CAMP mRNA and protein levels. MHP (Methyl caprooyl Tyrosinate) can enhance anti-microbial defense and innate immunity.
M11034 Netarsudil (AR-13324) 2HCl Netarsudil (AR-13324) is a ROCK inhibitor with a Ki value of 0.2-10.3 nM.
M10599 PF-543 HCl PF-543 hydrochloride is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2.
M3719 K145 hydrochloride K145 Hydrochloride is a selective, substrate competitive and oral inhibitor of SphK2, IC50 4.3 µM and Ki 6.4 µM. K145 hydrochloride has no activity against SphK1 and other protein kinases. K145 Hydrochloride induces apoptosis and has strong anti-tumor activity.
M2930 PF-543 PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform.



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