About 32 results found for searched term "S-Gem" (0.08 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M25059 | Sugemalimab | PD-1/PD-L1 |
| Sugemalimab is a fully human, full length, anti-programmed death ligand 1 (PD-L1) immunoglobulin G4 (IgG4) monoclonal antibody (mAb). Sugemalimab shows anticancer activities and can be used for non-small cell lung cancer research. | ||
| M41547 | S-Gem | Nucleoside Antimetabolite/Analog |
| S-Gem is a TrxR-dependent precursor of Gemcitabine and selectively activated by TrxR. | ||
| M2155 | (1S-cis)-Milnacipran Hydrochloride | 5-HT Receptor |
| Levomilnacipran hydrochloride; F-2695 hydrochloride | ||
| (1S-cis)-Milnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia. | ||
| M2875 | Nalmefene hydrochloride | Opioid Receptor |
| Nalmefene is an opioid receptor antagonist, it is used primarily in the management of alcohol dependence. | ||
| M3289 | Telmisartan | Angiotensin Receptor |
| BIBR 277 | ||
| Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. | ||
| M3354 | Carbamazepine | Sodium Channel |
| CBZ; NSC 169864 | ||
| Carbamazepine is a sodium channel inhibitor with an IC50 of 131 μM when treated with synaptosomes in rat brain. It can be used in trigeminal neuralgia research. Carbamazepine blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50=2 μM). | ||
| M3376 | Chlormezanone | GABA Receptor |
| Chlormezanone，a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. | ||
| M1577 | Naltrexone Hydrochloride | Opioid Receptor |
| Naltrexone hydrochlorideis an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. | ||
| M4247 | Schizandrol-B | PCSK9 |
| Gomisin-B; Schizantherin-B; Wuweizi ester-B; Schisantherin-B | ||
| Schisantherin B (Gomisin-B; Wuweizi ester-B; Schisantherin-B) is a lignan from Schisandra chinensis that promotes liver enlargement in mice through activation of the PXR and YAP pathways and inhibits PCSK9 protein expression with an IC50 value of 1.10 μM. | ||
| M4401 | Columbamine | Alkaloids |
| Columbamin; Dehydroisocorypalmine | ||
| Columbamine is a quaternary isoquinoline alkaloid isolated from Argemone mexicana. | ||
| M4976 | Ivabradine | HCN Channel |
| Ivabradine is a novel medicine indicated for the symptomatic management of stable angina pectoralis. | ||
| M5116 | Formoterol Hemifumarate | Adrenergic Receptor |
| Eformoterol, CGP 25827A, NSC 299587, YM 08316 | ||
| Formoterol Hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease. | ||
| M5394 | Alfacalcidol | Vitamin |
| 1-hydroxycholecalciferol; 1.alpha.-Hydroxyvitamin D3 | ||
| Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis. | ||
| M5598 | Dronedarone | Others |
| SR 33589 | ||
| Dronedarone is a newer therapeutic agent with a structural resemblance to amiodarone and a better side effect profile; it is a multichannel blocker with antiadrenergic properties and has been evaluated in both rate and rhythm control strategies in the management of AF. | ||
| M5680 | Gemcitabine | DNA/RNA Synthesis |
| NSC 613327; LY188011 | ||
| Gemcitabine (LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis. | ||
| M5804 | Naftidrofuryl oxalate | 5-HT Receptor |
| Nafronyl oxalate salt | ||
| Naftidrofuryl is a bioactive compound used in the management of peripheral and cerebral vascular disorders as a vasodilator, enhance cellular oxidative capacity, and may also be a 5-HT2 receptor antagonist. | ||
| M5938 | Rizatriptan Benzoate | 5-HT Receptor |
| MK-462 Benzoate | ||
| Rizatriptan Benzoate is an agonist at serotonin 5-HT1B and 5-HT1D receptors. Rizatriptan blocks neurogenic vasodilation via an action on 5-HT(1D) receptors located on perivascular trigeminal nerves to inhibit CGRP release in anaesthetized guinea-pigs. | ||
| M6991 | Monensin sodium | Antibiotic |
| Monensin A sodium | ||
| Monensin Sodium is an antibiotic secreted by Streptomyces Cinnamonensis. Monensin Sodium is an ionic carrier that mediates Na+/H+ exchange. Monensin sodium causes the enlargement of cellular multivesicular bodies (MVBs) and regulates secretion of exosomes. | ||
| M7822 | Gemfibrozil | PPAR |
| 吉非罗齐; CI-719 | ||
| Gemzil is a PPAR-α activator, which is a lipid-lowering agent. Gemfibrozil is also a nonselective inhibitor of P450, with Ki values of 5.8, 24,69 and 82 μM for CYP2C9, 2C19, 2C8 and 1A2, respectively. | ||
| M8507 | Tonabersat | Others |
| SB-220453 | ||
| Tonabersat is a potent inhibitor of neuronal-glial gap junctions in trigeminal ganglion that inhibits cortical spreading depression (CSD) and neurogenic inflammation in animal models of migraine. | ||
| M8960 | LY2334737 | DNA/RNA Synthesis |
| LY2334737 is an orally available valproic acid ester of gemcitabine, a broad-spectrum antimetabolite with antineoplastic activity. | ||
| M10840 | JNJ-17203212 | TRP Channel |
| JNJ-17203212 is a selective, highly effective, competitive TRPV1 antagonist. JNJ-17203212 was developed for research on pain management, such as migraines. | ||
| M11334 | Levomenol | Apoptosis |
| (-)-α-Bisabolol | ||
| Levomenol ((-)-α -bisabolol) isa monocyclic sesquiterpenoid alcohol with antioxidant, anti-inflammatory and anti-apoptotic effects. Levomenol also has neuroprotective effects, preventing neuronal damage and memory deficits by reducing pro-inflammatory markers of permanent focal cerebral ischemia induction in mice. Levomenol reduces nociceptive behavior and central sensitivity in a rodent model of trigeminal pain. | ||
| M11343 | Pinostrobin | PCSK9 |
| Pinostrobin is a flavonoid found in many plants and has antioxidant, anti-inflammatory, anticancer and neuroprotective properties. Pinostrobin is an effective INHIBITOR of PCSK9, which can inhibit the catalytic activity of PCSK9. Pinostrobin is a promising agent for cholesterol regulation and lipid management. | ||
| M11418 | SAR-020106 | Checkpoint |
| Sar-020106 is an ATP-competitive and selective CHK1 inhibitor with an IC50 of 13.3 nM. Sar-020106 has good selectivity to CHK2. Sar-020106 increased cell lethality of Gemcitabine and SN38 by 3.0 to 29 times in a p53-dependent manner in several colon cancer cell lines. Sar-020106 can enhance antitumor activity by selecting anticancer drugs. | ||
| M13387 | Revumenib (SNDX-5613) | Epigenetic Reader Domain |
| SNDX5613 | ||
| Revumenib (SNDX-5613) is a first-in-class, effective and selective Menin-MLL binding inhibitor with Ki of 0.15 nM. Revumenib (SNDX-5613) can be used to study MLL gene rearrangement in acute leukemia, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). | ||
| M13429 | VTP50469 fumarate | Epigenetic Reader Domain |
| VTP50469 fumarate is a Menin-MLL interaction inhibitor with a Ki of 104 pM. Effective against MLL rearrangement and NPM1c+ leukemia. It has effective anti-leukemia activity. | ||
| M13638 | Acelarin | DNA/RNA Synthesis |
| NUC-1031 | ||
| Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine. | ||
| M13701 | Gemcitabine elaidate | Others |
| CP-4126; CO-101; Gemcitabine 5'-elaidate | ||
| Gemcitabine elaidate (CP-4126) is lipophilic pro-drug of Gemcitabine. Gemcitabine elaidate is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate exhibits anti-tumor activity. | ||
| M13702 | Gemcitabine elaidate hydrochloride | Others |
| CP-4126 hydrochloride; CO-101 hydrochloride; Gemcitabine 5'-elaidate hydrochloride | ||
| Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-drug of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate hydrochloride exhibits anti-tumor activity. | ||
| M20445 | Indometacin Sodium | Others |
| Indometacin is a non-steroidal anti-inflammatory drug (NSAID) used most commonly for the treatment of inflammation and pain resulting from rheumatic disease (arthritis), and less commonly in postoperative pain management. When taken for chronic pain conditions, indometacin has been associated with a high incidence of adverse events. The benefits and harms of orally-administered indometacin for postoperative pain are not clear. | ||
| M20485 | Phenylglyoxal hydrate | Dehydrogenase |
| 1-Phenylethanedione hydrate | ||
| Phenylglyoxal is a potent inhibitor of mitochondrial aldehyde dehydrogenase. It reacts with arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties. | ||
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