It is marketed under the trade names Corlanor, Procoralan, Coralan, Corlentor, Coraxan, Ivabid, and Bradia by Servier Laboratories. Amgen markets ivabradine in the United States. Ivabradine acts by selectively inhibiting the pacemaker current (If) in a dose-dependent fashion. This inhibition results in a lower heart rate and thus more time for blood to flow to the myocardium.
| Molecular Weight | 468.59 |
| Formula | C27H36N2O5 |
| CAS Number | 155974-00-8 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Lucia Dallapellegrina, et al. Ivabradine and endothelium: an update
[3] Edimar Alcides Bocchi, et al. Ivabradine for treatment of heart failure
[4] Tomomi Ide, et al. Ivabradine for the Treatment of Cardiovascular Diseases
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| ZD7288
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