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It is marketed under the trade names Corlanor, Procoralan, Coralan, Corlentor, Coraxan, Ivabid, and Bradia by Servier Laboratories. Amgen markets ivabradine in the United States. Ivabradine acts by selectively inhibiting the pacemaker current (If) in a dose-dependent fashion. This inhibition results in a lower heart rate and thus more time for blood to flow to the myocardium.
| Molecular Weight | 468.59 |
| Formula | C27H36N2O5 |
| CAS Number | 155974-00-8 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Lucia Dallapellegrina, et al. Ivabradine and endothelium: an update
[3] Edimar Alcides Bocchi, et al. Ivabradine for treatment of heart failure
[4] Tomomi Ide, et al. Ivabradine for the Treatment of Cardiovascular Diseases
| Related HCN Channel Products |
|---|
| RO-275
RO-275 is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. The selective HCN1 inhibitor RO-275 improved performance in a translationally relevant touchscreen task of WM (TUNL) in rats. |
| KIO-301
KIO-301 a photoswitchable HCN channel blocker, and dihydroorotic acid ester dehydrogenase (DHODH) inhibitor for studies related to ocular diseases. |
| BPU-11
BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease. |
| ZD7288
ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker. |
| DK-AH 269
DK-AH 269 (Cilobradine) is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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