HCN Channel Hyperpolarization- and Cyclic Nucleotide-gated (HCN)

Inhibitor

Cat.No.	Name	Information
M6063	Zatebradine	Zatebradine(UL-FS49) is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner; 92% inhibition of the hHCN1-mediated current at 10 uM.
M5079	Zatebradine hydrochloride	Zatebradine(UL-FS49) is a highly effective HCN ion channel antagonist, which can reversively reduce heart rate and inhibit hHCN1 up to 92% at 10uM concentration.
M4976	Ivabradine	Ivabradine is a novel medicine indicated for the symptomatic management of stable angina pectoralis.
M55627	RO-275	RO-275 is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. The selective HCN1 inhibitor RO-275 improved performance in a translationally relevant touchscreen task of WM (TUNL) in rats.
M45262	KIO-301	KIO-301 a photoswitchable HCN channel blocker, and dihydroorotic acid ester dehydrogenase (DHODH) inhibitor for studies related to ocular diseases.
M30867	BPU-11	BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease.
M14225	ZD7288	ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker.
M7768	DK-AH 269	DK-AH 269 (Cilobradine) is an HCN Channel blocker; an open channel blocker of neuronal I_hand related cardiac I_fchannels.