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DK-AH 269 (Cilobradine) is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.
| Molecular Weight | 519.07 |
| Formula | C28H38N2O5 · HCl |
| CAS Number | 186097-54-1 |
| Solubility (25°C) | Water: ~20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related HCN Channel Products |
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| RO-275
RO-275 is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. The selective HCN1 inhibitor RO-275 improved performance in a translationally relevant touchscreen task of WM (TUNL) in rats. |
| KIO-301
KIO-301 a photoswitchable HCN channel blocker, and dihydroorotic acid ester dehydrogenase (DHODH) inhibitor for studies related to ocular diseases. |
| BPU-11
BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease. |
| ZD7288
ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker. |
| Zatebradine
Zatebradine(UL-FS49) is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner; 92% inhibition of the hHCN1-mediated current at 10 uM. |
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