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Tonabersat is a potent inhibitor of neuronal-glial gap junctions in trigeminal ganglion that inhibits cortical spreading depression (CSD) and neurogenic inflammation in animal models of migraine.
| Molecular Weight | 391.82 |
| Formula | C20H19ClFNO4 |
| CAS Number | 175013-84-0 |
| Solubility (25°C) | DMSO: 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Qing Chen, et al. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer
[3] Yue Cao, et al. Tonabersat for migraine prophylaxis: a systematic review
[4] S D Silberstein. Tonabersat, a novel gap-junction modulator for the prevention of migraine
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