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SAR-020106

Cat. No. M11418
SAR-020106  Structure
Size Price Availability Quantity
5mg USD 200  USD200 In stock
10mg USD 300  USD300 In stock
25mg USD 580  USD580 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Sar-020106 is an ATP-competitive and selective CHK1 inhibitor with an IC50 of 13.3 nM. Sar-020106 has good selectivity to CHK2. Sar-020106 increased cell lethality of Gemcitabine and SN38 by 3.0 to 29 times in a p53-dependent manner in several colon cancer cell lines. Sar-020106 can enhance antitumor activity by selecting anticancer drugs.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 382.85
Formula C19H19ClN6O
CAS Number 1184843-57-9
Purity >98%
Solubility DMSO : 20 mg/mL
Storage at -20°C
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