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Inhibitors

Cat.No.  Name Information
M1665 AZD7762 AZD7762 is a potent ATP-competitive checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2 respectively.
M1716 Gemcitabine Hydrochloride Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM.
M2325 CHIR-124 CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM.
M5137 BML-277 BML-277 is a high efficient Chk2 inhibitors, IC50 is 15 nM.
M10476 GDC-0575 (ARRY-575) GDC-0575 (ARRY-575, RG7741) is a potent and selective oral inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM.
M10129 CCT245737 CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor, with IC50 values of 1.3 nM, 2440 nM and 30 nM for CHK1, CHK2 and G2 check point abrogation, respectively.
M9208 PD0166285 PD0166285 is a potent Wee1 inhibitor and Chk1 inhibitor with IC50s of 24 nM and 72 nM, respectively.
M9042 Prexasertib dihydrochloride Prexasertib (LY2606368) is a substrate ATP competitively selective inhibitor of CHK1 and CHK2 with IC50 values of <1 nM and 8 nM against CHK1 and CHK2, respectively.
M6104 Ipilimumab Ipilimumab (MDX-010, BMS-734016) is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD.
M5156 CCT241533 hydrochloride CCT241533 hydrochloride is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM.
M5137 BML-277 BML-277 is a high efficient Chk2 inhibitors, IC50 is 15 nM.
M3686 AZD7762 hydrochloride AZD7762 hydrochloride is a potent ATP-competitive checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2 respectively.
M2325 CHIR-124 CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM.
M2324 Rabusertib Rabusertib (LY2603618) is an effective and selective Chk1 inhibitor with an IC50 of 7 nM.
M1996 SCH 900776 SCH 900776 (MK-8776) is a highly potent and functionally selective CHK1 inhibitor with IC50 of 3 nM.
M1716 Gemcitabine Hydrochloride Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM.
M1698 Clofarabine Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
M1676 BIBR1532 BIBR1532 is a potent and selective telomerase inhibitor with IC50 of 93 nM.
M1665 AZD7762 AZD7762 is a potent ATP-competitive checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2 respectively.


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