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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M10476 | GDC-0575 (ARRY-575) | GDC-0575 (ARRY-575, RG7741) is a potent and selective oral inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. |
| M10129 | CCT245737 | CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor, with IC50 values of 1.3 nM, 2440 nM and 30 nM for CHK1, CHK2 and G2 check point abrogation, respectively. |
| M9208 | PD0166285 | PD0166285 is a potent Wee1 inhibitor and Chk1 inhibitor with IC50s of 24 nM and 72 nM, respectively. |
| M9042 | Prexasertib dihydrochloride | Prexasertib dihydrochloride (LY2606368 HCl) is a potent and selective ATP competitive inhibitor of the Chk1 protein kinase with IC50s of <1 nM and 8 nM for CHK1 and CHK2, respectively. |
| M6104 | Ipilimumab | Ipilimumab (MDX-010, BMS-734016) is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD. |
| M5137 | BML-277 | BML-277 is a high efficient Chk2 inhibitors, IC50 is 15 nM. |
| M3686 | AZD7762 hydrochloride | AZD7762 hydrochloride is a potent ATP-competitive checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2 respectively. |
| M2325 | CHIR-124 | CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM. |
| M2324 | LY2603618 | LY2603618 (IC-83) is a selective Chk1 inhibitor with potential anti-tumor activity. |
| M1996 | SCH 900776 | SCH 900776 (MK-8776) is a highly potent and functionally selective CHK1 inhibitor with IC50 of 3 nM. |
| M1716 | Gemcitabine Hydrochloride | Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM. |
| M1698 | Clofarabine | Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. |
| M1676 | BIBR1532 | BIBR1532 is a potent and selective telomerase inhibitor with IC50 of 93 nM. |
| M1665 | AZD7762 | AZD7762 is a potent ATP-competitive checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2 respectively. |
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