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Cat. No. M21501
Monalizumab  Structure


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1mg USD 490  USD490 In stock
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Quality Control & Documentation
Biological Activity

Monalizumab is a first-in-class immune checkpoint inhibitor targeting natural killer cell population 2A (NKG2A). Monalizumab can be used in the study of head and neck squamous cell carcinoma (HNSCC).

Chemical Information
CAS Number 1228763-95-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Jeongjae Lee, et al. J Cancer Res Clin Oncol. Monalizumab efficacy correlates with HLA-E surface expression and NK cell activity in head and neck squamous carcinoma cell lines

[2] Roy S Herbst, et al. J Clin Oncol. COAST: An Open-Label, Phase II, Multidrug Platform Study of Durvalumab Alone or in Combination With Oleclumab or Monalizumab in Patients With Unresectable, Stage III Non-Small-Cell Lung Cancer

[3] Linda Borst, et al. Clin Cancer Res. The NKG2A-HLA-E Axis as a Novel Checkpoint in the Tumor Microenvironment

[4] Thorbald van Hall, et al. J Immunother Cancer. Monalizumab: inhibiting the novel immune checkpoint NKG2A

[5] Pascale Andr, et al. Cell. Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

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Keywords: Monalizumab , IPH2201 supplier, Checkpoint, inhibitors, activators

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