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GDC-0575 dihydrochloride

Cat. No. M13621
GDC-0575 dihydrochloride Structure

ARRY-575 dihydrochloride; RG7741 dihydrochloride

Size Price Availability
5mg USD 210  USD210 4-7 Days
10mg USD 360  USD360 4-7 Days
25mg USD 720  USD720 4-7 Days
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Quality Control & Documentation
Biological Activity

GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity.

Chemical Information
Molecular Weight 451.19
CAS Number 1657014-42-0
Solubility (25°C) DMSO 65 mg/mL
Water 25 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Min Li, et al. Onco Targets Ther. GDC-0575, a CHK1 Inhibitor, Impairs the Development of Colitis and Colitis-Associated Cancer by Inhibiting CCR2 + Macrophage Infiltration in Mice

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GDC0575 hydrochloride

GDC0575 (ARRY-575) hydrochloride is a highly-selective and orally active Chk1 (IC50=1.2 nM) inhibitor. GDC0575 (ARRY-575) hydrochloride can be used for colitis-associated cancer (CAC) and colitis research.

Abmole Inhibitor Catalog

Keywords: GDC-0575 dihydrochloride, ARRY-575 dihydrochloride; RG7741 dihydrochloride supplier, Checkpoint, inhibitors, activators

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