About 30 results found for searched term "S-72" (0.012 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1682 | BMS-777607 | c-Met |
| BMS 817378; CAS# 1025720-94-8 | ||
| BMS-777607 is a selective and potent small-molecule met kinase inhibitor for c-Met, Axl, Ron and Tyro3 with IC50s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively. | ||
| M1711 | Febuxostat (TEI-6720) | Xanthine Oxidase |
| TEI-6720; Uloric; TMX-67 | ||
| Febuxostat (TEI-6720) is a non-purine selective xanthine oxidase inhibitor with IC50 of 114 -210 nM. | ||
| M1807 | SCH727965 (dinaciclib) | CDK |
| Dinaciclib | ||
| SCH727965 (Dinaciclib) is a potent and selective CDK inhibitor with IC50 values of 1, 1, 3 and 4 nM for CDK2, CDK5, CDK1 and CDK9, respectively. | ||
| M1824 | SRT1720 Hydrochloride | Sirtuin |
| SRT-1720 Hydrochloride | ||
| SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway. | ||
| M1925 | LY294002 | PI3K |
| NSC 697286; SF 1101 | ||
| LY294002 is a highly selective PI3K inhibitor with IC50 values of 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively. LY294002 also inhibits CK2 with an IC50 of 98 nM. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM. | ||
| M2084 | SCH772984 | ERK |
| SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. | ||
| M2197 | Sulfasalazine | Ferroptosis |
| Salazopyrin; Azulfidine; Sulphasalazine; SAS; NSC 667219 | ||
| Sulfasalazine is a sulfonamide agent derived from Mesalazine. Sulfasalazine has xC-system inhibitory activity associated with iron death and is primarily used as an anti-inflammatory agent. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer. | ||
| M2337 | Crisaborole (AN2728) | PDE |
| AN-2728 | ||
| Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release. Crisaborole (AN-2728) inhibit PDE4 with an IC50 of 0.49 μM. | ||
| M2341 | Trelagliptin | Dipeptidyl Peptidase |
| SYR-472 | ||
| Trelagliptin (SYR-472) is a novel once-weekly oral DPP-4 inhibitor for type 2 diabetes. | ||
| M2662 | Efaproxiral Sodium | ROS |
| RSR13; NSC722758 | ||
| Efaproxiral sodium (RSR13 sodium) is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours. | ||
| M2862 | MNS | Src-bcr-Abl |
| NSC 170724; 5-(2-Nitrovinyl)benzodioxole | ||
| MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. | ||
| M2891 | NSC 319726 | Cuproptosis |
| NSC-319726; ZMC1 | ||
| NSC 319726 is a p53(R175) mutant activator that inhibits the growth of p53(R175) mutant cells and acts on p53(R175) mutant cells with IC50 of 8 nM, which has no inhibition on p53 wild-type cells. NSC 319726 is a potent copper ion-carrier that can be used in cuproptosis studies. | ||
| M3046 | Tacrine hydrochloride | AChR/AChE |
| Hydroaminacrine; NSC72108 HCl | ||
| Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist. | ||
| M3096 | Tyrphostin 9 | VEGFR/PDGFR |
| SF 6847, RG-50872 | ||
| Tyrphostin 9 is firstly designed as an EGFR inhibitor with IC50 of 460 μM, but is also found to be more potent to PDGFR with IC50 of 0.5 μM. | ||
| M3112 | Valdecoxib | COX |
| SC 65872 | ||
| Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM. | ||
| M3213 | Meclizine dihydrochloride | Histamine Receptor |
| Meclozine dihydrochloride; NSC28728 | ||
| Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR. Phase2. | ||
| M3484 | Dolutegravir | Integrase |
| GSK1349572 | ||
| Dolutegravir (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. | ||
| M3603 | Procarbazine hydrochloride | DNA/RNA Synthesis |
| NSC-77213 HCl | ||
| Procarbazine hydrochloride is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent. | ||
| M3977 | Chlorogenic acid | HIF |
| NSC-407296; CQAs; 3-O-Caffeoylquinic acid; Heriguard | ||
| Chlorogenic Acid is an analog of caffeic acid that displays antioxidant, analgesic, antipyretic and chemopreventive activity. | ||
| M1567 | Nadolol | Adrenergic Receptor |
| SQ-11725 | ||
| Nadolol | ||
| M4607 | Phloretin | SGLT |
| NSC 407292; RJC 02792 | ||
| Phloretin (NSC 407292; RJC 02792) is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). | ||
| M4824 | Dolutegravir sodium | Integrase |
| GSK-1349572A, DTG | ||
| Dolutegravir sodium is a potent, second generation HIV integrase inhibitor (IC₅₀ = 2.7 nM) that displays potent antiviral activity. | ||
| M5235 | NSC12 | FGFR |
| NSC 172285 | ||
| NSC12 is an orally available pan-FGF trap able to inhibit FGF2/FGFR interaction and endowed with promising antitumor activity. | ||
| M5502 | Ceftibuten dihydrate | Antibiotic |
| Sch-39720 dihydrate | ||
| Ceftibuten dihydrate is a third-generation cephalosporin antibiotic. | ||
| M6127 | TD-4208 | AChR/AChE |
| Revefenacin; GSK1160724 | ||
| Revefenacin (TD-4208; GSK1160724) is a novel and potent muscarinic receptor antagonist that has a high affinity and long residence time at the M3 receptor, and demonstrates in vitro kinetic selectivity for M3 over M2 muscarinic receptor subtype and no meaningful off-target activity. | ||
| M6774 | GSK 789472 hydrochloride | Others |
| GSK 789472 hydrochloride is a d 3 antagonist. Also D 2 partial agonist. | ||
| M7270 | SB 772077B dihydrochloride | Others |
| SB 772077B dihydrochloride is a potent Rho-kinase inhibitor; vasodilator. | ||
| M7298 | SJ 172550 | Others |
| SJ 172550 is a mDMX inhibitor. Disrupts MDMX-p53 interaction. | ||
| M7331 | SR 57227 hydrochloride | Others |
| SR 57227 hydrochloride is a potent, selective 5-HT 3 agonist. | ||
| M7971 | NSC727447 | Others |
| NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. | ||
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
