About 30 results found for searched term "S-72" (0.007 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1682 | BMS-777607 | c-Met |
| BMS 817378; CAS# 1025720-94-8 | ||
| BMS-777607 is a selective and potent small-molecule met kinase inhibitor for c-Met, Axl, Ron and Tyro3 with IC50s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively. | ||
| M1711 | Febuxostat (TEI-6720) | Xanthine Oxidase |
| TEI-6720; Uloric; TMX-67 | ||
| Febuxostat (TEI-6720) is a non-purine selective xanthine oxidase inhibitor with IC50 of 114 -210 nM. | ||
| M1807 | SCH727965 (dinaciclib) | CDK |
| Dinaciclib | ||
| SCH727965 (Dinaciclib) is a potent and selective CDK inhibitor with IC50 values of 1, 1, 3 and 4 nM for CDK2, CDK5, CDK1 and CDK9, respectively. | ||
| M1824 | SRT1720 Hydrochloride | Sirtuin |
| SRT-1720 Hydrochloride | ||
| SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway. | ||
| M2084 | SCH772984 | ERK |
| SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. | ||
| M2197 | Sulfasalazine | Ferroptosis |
| Salazopyrin; Azulfidine; Sulphasalazine; SAS; NSC 667219 | ||
| Sulfasalazine is a sulfonamide agent derived from Mesalazine. Sulfasalazine has xC-system inhibitory activity associated with iron death and is primarily used as an anti-inflammatory agent. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer. | ||
| M2337 | Crisaborole (AN2728) | PDE |
| AN-2728 | ||
| Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release. Crisaborole (AN-2728) inhibit PDE4 with an IC50 of 0.49 μM. | ||
| M2341 | Trelagliptin | Dipeptidyl Peptidase |
| SYR-472 | ||
| Trelagliptin (SYR-472) is a novel once-weekly oral DPP-4 inhibitor for type 2 diabetes. | ||
| M2662 | Efaproxiral Sodium | ROS |
| RSR13; NSC722758 | ||
| Efaproxiral sodium (RSR13 sodium) is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours. | ||
| M2862 | MNS | Src-bcr-Abl |
| NSC 170724; 5-(2-Nitrovinyl)benzodioxole | ||
| MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. | ||
| M2891 | NSC 319726 | Cuproptosis |
| NSC-319726; ZMC1 | ||
| NSC 319726 is a p53(R175) mutant activator that inhibits the growth of p53(R175) mutant cells and acts on p53(R175) mutant cells with IC50 of 8 nM, which has no inhibition on p53 wild-type cells. NSC 319726 is a potent copper ion-carrier that can be used in cuproptosis studies. | ||
| M3046 | Tacrine hydrochloride | AChR/AChE |
| Hydroaminacrine; NSC72108 HCl | ||
| Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist. | ||
| M3112 | Valdecoxib | COX |
| SC 65872 | ||
| Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM. | ||
| M3213 | Meclizine dihydrochloride | Histamine Receptor |
| Meclozine dihydrochloride; NSC28728 | ||
| Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR. Phase2. | ||
| M3484 | Dolutegravir | Integrase |
| GSK1349572 | ||
| Dolutegravir (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. | ||
| M3603 | Procarbazine hydrochloride | DNA/RNA Synthesis |
| NSC-77213 HCl | ||
| Procarbazine hydrochloride is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent. | ||
| M3977 | Chlorogenic acid | HIF |
| NSC-407296; CQAs; 3-O-Caffeoylquinic acid; Heriguard | ||
| Chlorogenic acid is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound. | ||
| M1567 | Nadolol | Adrenergic Receptor |
| SQ-11725 | ||
| Nadolol | ||
| M4607 | Phloretin | SGLT |
| NSC 407292; RJC 02792 | ||
| Phloretin (NSC 407292; RJC 02792) is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). | ||
| M4824 | Dolutegravir sodium | Integrase |
| GSK-1349572A, DTG | ||
| Dolutegravir sodium is a potent, second generation HIV integrase inhibitor (IC₅₀ = 2.7 nM) that displays potent antiviral activity. | ||
| M5235 | NSC12 | FGFR |
| NSC 172285 | ||
| NSC12 is an orally available pan-FGF trap able to inhibit FGF2/FGFR interaction and endowed with promising antitumor activity. | ||
| M5502 | Ceftibuten dihydrate | Antibiotic |
| Sch-39720 dihydrate | ||
| Ceftibuten dihydrate is a third-generation cephalosporin antibiotic. Ceftibuten (Sch-39720) dihydrate is an antibiotic, is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens. | ||
| M6127 | TD-4208 | AChR/AChE |
| Revefenacin; GSK1160724 | ||
| Revefenacin (TD-4208; GSK1160724) is a novel and potent muscarinic receptor antagonist that has a high affinity and long residence time at the M3 receptor, and demonstrates in vitro kinetic selectivity for M3 over M2 muscarinic receptor subtype and no meaningful off-target activity. | ||
| M6774 | GSK 789472 hydrochloride | Others |
| GSK 789472 hydrochloride is a d 3 antagonist. Also D 2 partial agonist. | ||
| M7270 | SB 772077B dihydrochloride | Others |
| SB 772077B dihydrochloride is a potent Rho-kinase inhibitor; vasodilator. | ||
| M7298 | SJ 172550 | Others |
| SJ 172550 is a mDMX inhibitor. Disrupts MDMX-p53 interaction. | ||
| M7331 | SR 57227 hydrochloride | Others |
| SR 57227 hydrochloride is a potent, selective 5-HT 3 agonist. | ||
| M7971 | NSC727447 | Others |
| NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. | ||
| M8492 | SQ109 | Others |
| NSC 722041 | ||
| SQ109 is an anti-tuberculosis compound used in the study of multi-drug resistant tuberculosis (MDR-TB). | ||
| M8503 | SB-207266 | 5-HT Receptor |
| SB-207266 is a potent, selective, orally active and long-acting 5-HT4 antagonist in vivo. | ||
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