About 19 results found for searched term "NSC12" (0.057 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1686 | Bortezomib (PS-341) | Proteasome |
| Velcade; PS-341; LDP 341; MG 341; NSC 681239 | ||
| Bortezomib (PS-341) is a highly selective proteasome inhibitor with a ki value of 6nM. | ||
| M1970 | Paclitaxel | Microtubule |
| Taxol; NSC 125973 | ||
| Paclitaxel is a diterpenoid derived from the bark of the plant Picea abies, and is also a microtubule polymer stabilizer, which promotes polymerization of microtubule proteins to inhibit depolymerization, maintains the stability of microtubule proteins, and inhibits cellular mitosis, and acts on human endothelial cells with an IC50 of 0.1 pM. | ||
| M2052 | Decitabine | DNA Methyltransferase |
| 5-Aza-2'-deoxycytidine; NSC 127716; 5-AZA-CdR | ||
| Decitabine (5-Aza-2'-deoxycytidine) is a potent inhibitor of DNA methylation for the treatment of myelodysplastic syndromes. | ||
| M2100 | Bleomycin sulfate | Animal Modeling |
| Blenoxane; NSC125066; BLEO | ||
| Bleomycin sulfate (Blenoxane) is a glycopeptide antitumor antibiotic isolated from Streptomyces verticillus. | ||
| M2288 | Carboplatin | DNA/RNA Synthesis |
| NSC 241240; Paraplatin | ||
| Carboplatin (NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism. | ||
| M2320 | 17-AAG (Tanespimycin) | HSP |
| Tanespimycin; 17AAG; NSC 330507; CP 127374 | ||
| 17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM. | ||
| M2540 | Creatinine | Others |
| NSC13123 | ||
| Creatinine is a break-down product of creatine phosphate in muscle. | ||
| M2700 | FH1 | Others |
| NSC 12407; BRD-K4477 | ||
| FH1(BRD-K4477) is a small molecule, which promotes differentiation of iPS-derived hepatocytes. | ||
| M3238 | 4-Quinazolinamine | EGFR/HER2 |
| 4-Aminoquinazoline, NSC 288012 | ||
| 4-Quinazolinamine (4-Aminoquinazoline) is a potent and highly selective EGFR tyrosine kinase inhibitor. | ||
| M3561 | Geldanamycin | HSP |
| NSC 122750 | ||
| Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. | ||
| M5235 | NSC12 | FGFR |
| NSC 172285 | ||
| NSC12 is an orally available pan-FGF trap able to inhibit FGF2/FGFR interaction and endowed with promising antitumor activity. | ||
| M13791 | Lucigenin | Fluorescent Dye |
| NSC-151912; L-6868 | ||
| Lucigenin(L-6868; NSC-151912) is a chemiluminescent probe used to indicate the presence of endogenously generated superoxide anion radicals in cells. | ||
| M16158 | Koenimbine | Alkaloids |
| NSC 127152; Koenimbin; Kenimbine | ||
| Koenimbine is a natural product isolated from Murraya koenigii. The IC50 values of koenimbine in HT-29 and SW48 was calculated to be 50 μg/ml based on the MTT assay. The IC50 value was 75 μg/ml in IEC-18 cells. | ||
| M20001 | Testolactone | Others |
| sq9538;teolit;teslac;teslak;nsc-12173 | ||
| Testolactone was originally synthesized as a possible anabolic steroid. The key structural difference from anabolic steroids is the D-cyclolactone rather than the typical cyclopentyl ring. | ||
| M20410 | PTP Inhibitor II | Phosphatase |
| NSC 129010, 4-(Bromoacetyl)anisole | ||
| PTP Inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with Ki value of 128 μM. | ||
| M27799 | Dolastatin 10 | Microtubule |
| DLS 10; NSC 376128 | ||
| Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization. | ||
| M28943 | Sangivamycin | PKC |
| NSC 65346; BA-90912 | ||
| Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers. | ||
| M29959 | Resorufin sodium salt | ROS |
| NSC 12097 sodium salt | ||
| Resorufin sodium salt (NSC 12097 sodium salt) is a highly fluorescent pink dye for the detection of ROS/RNS and a second analyte. | ||
| M49366 | Boc-Glycine | Others |
| N-tert-Butoxycarbonyl-2-aminoacetic acid; NSC 127669 | ||
| Boc-Glycine is a glycine derivative that can be used in peptide synthesis. | ||
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