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Sangivamycin

Cat. No. M28943

All AbMole products are for research use only, cannot be used for human consumption.

Sangivamycin Structure
Synonym:

NSC 65346; BA-90912

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Quality Control & Documentation
Biological Activity

Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers.

Chemical Information
Molecular Weight 309.28
Formula C12H15N5O5
CAS Number 18417-89-5
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ryan P Bennett, et al. JCI Insight. Sangivamycin is highly effective against SARS-CoV-2 in vitro and has favorable drug properties

[2] Ligia I Bastea, et al. Sci Rep. Sangivamycin and its derivatives inhibit Haspin-Histone H3-survivin signaling and induce pancreatic cancer cell death

[3] Kazufumi Wakao, et al. Biochem Biophys Res Commun. Sangivamycin induces apoptosis by suppressing Erk signaling in primary effusion lymphoma cells

[4] K V Rao. J Med Chem. Structure of sangivamycin

[5] C R Loomis, et al. J Biol Chem. Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C

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  Catalog
Abmole Inhibitor Catalog




Keywords: Sangivamycin, NSC 65346; BA-90912 supplier, PKC, inhibitors, activators

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