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Resorufin sodium salt

Cat. No. M29959
Resorufin sodium salt Structure
Synonym:

NSC 12097 sodium salt

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Biological Activity

Resorufin sodium salt (NSC 12097 sodium salt) is a highly fluorescent pink dye for the detection of ROS/RNS and a second analyte.

Chemical Information
Molecular Weight 235.17
Formula C12H6NNaO3
CAS Number 34994-50-8
Form Solid
Solubility (25°C) DMSO 62.5 mg/mL (ultrasonic)
Water 7.69 mg/mL (ultrasonic)
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qiang Wen, et al. J Am Chem Soc. Chiral and SHG-Active Metal-Organic Frameworks Formed in Solution and on Surfaces: Uniformity, Morphology Control, Oriented Growth, and Postassembly Functionalization

[2] Kazuko Ishiguro, et al. J Microbiol Methods. Real-time monitoring of the metabolic activity of periodontopathic bacteria

[3] Christian Reichhart, et al. Colloids Surf B Biointerfaces. A quantitative study of the enzymatic activity of horseradish peroxidase at a planar poly(acrylic acid) brush

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