All AbMole products are for research use only, cannot be used for human consumption.
Protocatechualdehyde (PCA) exerts anti-cancer activity through down-regulating cyclin D1 and HDAC2 in human colorectal cancer cells. The inhibition of cell viability and apoptosis by PCA may be result of ATF3 expression through ERK1/2 and p38-mediated transcriptional activation. PCA suppress β-catenin expression through GSK3β- and NF-κB-mediated proteosomal degradation. In addition, PCA decreased cyclin D1 expression independent to β-catenin through proteosomal degradation. PCA could be useful in attenuation of MGO-induced cell damage and the possible mechanism is involved in modulating AGEs-receptor of AGEs axis in human lens epithelial cells, which suggests that PCA has a potential protective effect on diabetic cataract.
| Molecular Weight | 138.12 |
| Formula | C7H6O3 |
| CAS Number | 139-85-5 |
| Form | Solid |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related ROS Products |
|---|
| N-Acetyl-L-cysteine ethyl ester
N-Acetyl-L-cysteine ethyl ester exhibits enhanced cell permeability, and produce NAC and cysteine. N-Acetyl-L-cysteine ethyl ester increases circulating hydrogen sulfide (H2S) and can be used as an H2S producer. |
| Manganese(salen) chloride
Manganese(salen) chloride (EUK-8) is a superoxide dismutase and catalase mimetic, it is an antioxidant with oxyradical scavenging properties. |
| Magnoloside F
Magnoloside F is a natural compound that can be isolated from the Magnolia officinalis, and has antioxidant activity. |
| Porphyra 334
Porphyra 334 is an antioxidative and anti-photoaging agent. |
| Photosensitizer-1
Photosensitizer-1 is a photosensitizer. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
