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L-Ascorbyl 6-palmitate

Cat. No. M3490

All AbMole products are for research use only, cannot be used for human consumption.

L-Ascorbyl 6-palmitate Structure
Synonym:

L-Ascorbic acid 6-hexadecanoate; 6-O-Palmitoyl-L-ascorbic acid

Size Price Availability Quantity
1g USD 50  USD50 In stock
5g USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

L-Ascorbyl 6-palmitate is a synthetic lipophilic ascorbic acid derivative. L-Ascorbyl 6-palmitate is an effective preservative in foods and an effective dietary antitumor promoter in mice. Studies indicate that dietary AP is a source of tissue vitamin C in animals. Besides, dietary L-Ascorbyl 6-palmitate possesses weak antiscorbutic activity in guinea pigs and enhances vitamin C nutriture in humans. In a study, daily mean weight loss during repletion in control animals receiving placebo was significantly greater than that for both L-ascorbic acid (AA) and L-Ascorbyl 6-palmitate animals for days 3–10 of repletion. Daily mean weight loss for AP animals was significantly greater than that for AA animals on days 5 and 6 of repletion. By comparing areas of the weight-time curve during repletion, L-Ascorbyl 6-palmitate appeared to be about 50% as effective as AA in reversing scurvy.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male MF1 mice
Formulation
Dosages 1412 mg/kg
Administration Orally
Chemical Information
Molecular Weight 414.53
Formula C22H38O7
CAS Number 137-66-6
Form Solid
Solubility (25°C) DMSO 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ayumi Nanri, et al. Preparation and Characterization of a Hybrid Complex of Cyclodextrin-Based Metal-Organic Frameworks-1 and Ascorbic Acid Derivatives

[2] Yutaka Inoue, et al. A Nanocarrier Skin-Targeted Drug Delivery System using an Ascorbic Acid Derivative

[3] Kazufusa Shinomiya, et al. Countercurrent Chromatographic Separation of Lipophilic Ascorbic Acid Derivatives and Extract from Kadsura Coccinea Using Hydrophobic Organic-Aqueous Two-Phase Solvent Systems

[4] Andreas F-P Sonnen, et al. Effect of temperature, cholesterol content, and antioxidant structure on the mobility of vitamin E constituents in biomembrane models studied by laterally diffusion-controlled fluorescence quenching

[5] Qing-Xun Song, et al. Enzymatic synthesis and antioxidant properties of L-ascorbyl oleate and L-ascorbyl linoleate

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Keywords: L-Ascorbyl 6-palmitate, L-Ascorbic acid 6-hexadecanoate; 6-O-Palmitoyl-L-ascorbic acid supplier, ROS, inhibitors, activators

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