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Koenimbine is a natural product isolated from Murraya koenigii.
The IC50 values of koenimbine in HT-29 and SW48 was calculated to be 50 μg/ml based on the MTT assay. The IC50 value was 75 μg/ml in IEC-18 cells.
Koenimbine treatment resulted in significant down-regulation of CYCLD1 expression in SW48 cell line, but up-regulation of this gene in HT29 cell line. Expression of TBLR1, DKK1, GSK3B and β-catenin was significantly decreased after koenimbine treatment in HT-19 cell line. Moreover, expression of DKK1 and GSK3B was significantly decreased after koenimbine treatment in SW-40 cell line.
Koenimbine considerably increased DNA damage in HepG2 cells at subcytotoxic concentrations. Koenimbine induced the increased levels of reactive oxygen species (ROS) and reduction of GSH level in HepG2 cells, together with time-dependent loss of MMP. In addition, Koenimbine encouraged cells to express Hsp 70 and Hsp 90 in a concentration-dependent manner up to a concentration of 100 µM and a time-dependent manner at 24-hour incubation both at transcriptional and translational levels.
| Molecular Weight | 293.36 |
| Formula | C19H19NO2 |
| CAS Number | 21087-98-9 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Alkaloids Products |
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| Cinchonidine
Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. Cinchonidine (α-Quinidine) is a weak inhibitor of serotonin transporter (SERT) with Ki values of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. |
| Loline
Loline is a natural alkaloid and deterrent to a broad range of insects. |
| Urea
Urea |
| Flazin
Flazin |
| Indigo
Indigo |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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