About 30 results found for searched term "NHI-2" (0.023 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2059 | A-922500 | DGAT |
| DGAT-1 Inhibitor 4a; A922500 | ||
| A-922500 (DGAT-1 Inhibitor 4a) is a potent and selective DGAT-1 inhibitor with IC50 values of 9 and 22 nM at human and mouse DGAT-1 respectively. | ||
| M2114 | GSK126 | EZH2 |
| EZH2 inhibitor; GSK2816126A | ||
| GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity. | ||
| M2237 | IWP-2 | Wnt/beta-catenin |
| Inhibitor of Wnt Production-2 | ||
| IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM. | ||
| M2504 | CFTR(inh)-172 | CFTR |
| CFTR inhibitor 172 | ||
| CFTR(inh)-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. | ||
| M2785 | JNK Inhibitor IX (SC202671) | JNK |
| TCS JNK 5a; SC-202671 | ||
| JNK inhibitor IX is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively. | ||
| M3639 | MALT1 inhibitor (MI-2) | MALT1 |
| ABM-3912; MI-2 | ||
| MALT1 inhibitor is an irreversible MALT1 inhibitor with IC50 of 5.84 μM. | ||
| M5144 | BMS202 | PD-1/PD-L1 |
| PD-1/PD-L1 inhibitor 2 | ||
| Bms-202 is an effective non-peptide PD-1/PD-L complex inhibitor with IC50 of 18 nM and KD of 8 μM. Bms-202 directly binds to PD-L1 and blocks the human PD-1/PD-L interaction. Bms-202 has antitumor activity. | ||
| M7140 | PIM-1 Inhibitor 2 | Others |
| PIM-1 Inhibitor 2 is a pim-1 kinase inhibitor. | ||
| M7627 | BIO | GSK-3 |
| 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime6BIO; GSK 3 IX; GSK 3 Inhibitor IX; MLS 2052 | ||
| BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052) is a specific GSK-3 inhibitor, the IC50 acting on GSK-3α/β in cell-free assays is 5 nM, which is more than 16 times more selective than ACTing on CDK5. It is also a pan-JAK inhibitor with an IC50 value of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells. | ||
| M8543 | NHI-2 | LDH |
| NHI-2 is an inihbitor of Lactate dehydrogenase-A (LDH-A, LDHA), a key enzyme necessary to sustain glycolysis, the major pathway used by many cancer cells for cell growth and proliferation (the Warburg effect). | ||
| M8775 | DMAT | Others |
| Casein kinase II Inhibitor; CK2 Inhibitor | ||
| Casein kinase II inhibitor II (Ck2 Inhibitor II) is a high affinity ATP-competitive inhibitor of casein kinase II. | ||
| M8887 | Btk inhibitor 2 | BTK |
| BGB-3111 | ||
| Btk inhibitor 2 (BGB-3111) is a Brutons tyrosine kinase (BTK) inhibitor. | ||
| M9145 | MI-2 | Histone Methyltransferase |
| Menin-MLL Inhibitor 2 | ||
| MI-2 (Menin-MLL Inhibitor 2) is a potent menin-MLL interaction inhibitor with IC50 of 446±28 nM. | ||
| M9270 | COH29 | DNA/RNA Synthesis |
| RNR Inhibitor COH29 | ||
| COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity. | ||
| M9642 | EGFR inhibitor 324674 | EGFR/HER2 |
| EGFR-IN-12 | ||
| EGFR inhibitor 324674 is a cell permeable, potent and selective EGFR inhibitor with IC50 of 21 nM. | ||
| M10741 | ERK1/2 inhibitor 2 | ERK |
| ERK1/2 inhibitor 2 (Example 1) is a potent dual ERK1/2 inhibitor. ERK1/2 inhibitor 2 has anti-cancer activity. | ||
| M11251 | Gartisertib | ATM/ATR |
| VX-803; M4344; ATR inhibitor 2 | ||
| Gartisertib (VX-803) is an ATP-competitive, orally active, selective ATR inhibitor with Ki<150 pM. Gartisertib inhibits atR-driven phosphorylation of checkpoint kinase-1 (Chk1) with an IC50 value of 8 nM. It has antitumor activity. | ||
| M13682 | HSP27 inhibitor J2 | HSP |
| HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. | ||
| M13731 | ROCK inhibitor-2 | ROCK |
| ROCK inhibitor-2 is a selective dual ROCK1 and ROCK2 inhibitor with IC50s of 17 nM and 2 nM, respectively. | ||
| M14163 | Cot inhibitor-2 | MAPKAPK2/MAP3K/MAP4K |
| Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM. | ||
| M14291 | DGAT-1 inhibitor 2 | DGAT |
| DGAT-1 inhibitor 2 is an effective inhibitor of DGAT-1;antiobesity agents. | ||
| M15012 | Recombinant Human TIMP-2 (HEK293,C-6His) | Cytokines and Growth Factors |
| Metalloproteinase Inhibitor 2; CSC-21K | ||
| TIMP-2 is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types, which inhibits MMPs non-covalently by the formation of binary complexes and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-2 also has erythroid‑potentiating and cell growth promoting activities. | ||
| M14854 | PI3K/mTOR Inhibitor-2 | PI3K |
| PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR. Antitumor activity. | ||
| M14905 | PKA Inhibitor Fragment (6-22) amide TFA | PKA |
| PKI-(6-22)-amide TFA | ||
| PKA Inhibitor Fragment (6-22) amide TFA is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide TFA can significantly reverse low-level morphine antinociceptive tolerance in mice. | ||
| M14935 | YB-0158 | Wnt/beta-catenin |
| Wnt pathway inhibitor 2 | ||
| YB-0158 (Wnt pathway inhibitor 2) is a reverse-turn peptidomimetic and a potent colorectal cancer stem cell (CSC) targeting agent. YB-0158 disrupts Sam68-Src interactions and induces apoptosis in CRC cells. Anti-cancer activities. | ||
| M20595 | K-Ras(G12C) inhibitor 12 | ROCK |
| K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C). | ||
| M20631 | BTK inhibitor 1 (Compound 27) | BTK |
| BTK inhibitor 1 (compound 27) is an inhibitor of BTK with an IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with an IC50 of 2 nM. | ||
| M20738 | Eph-inhibitor-1 | Ephrin Receptor |
| Eph inhibitor 2 | ||
| Eph-inhibitor-1 (Eph inhibitor 2) is an Eph family tyrosine kinase inhibitor that targets Eph receptors. | ||
| M21208 | BCATc Inhibitor 2 | Others |
| BCATc Inhibitor 2 is a sulfonyl hydrazide that inhibits BCATc with IC50s of 0.81 for human and IC50 s of 0.2 µM for rat. It is 15-fold selectivity over BCATm. It has also been used to block calcium influx into neurons with IC50 of 4.8 µM following inhibition of glutamate uptake and to demonstrate neuroprotective efficacy in an in vivo rat model of neurodegeneration. | ||
| M21687 | Nexinhib20 | GTPase |
| Rab27 Inhibitor | ||
| Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 µM). | ||
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