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Btk inhibitor 2

Cat. No. M8887
Btk inhibitor 2 Structure
Synonym:

BGB-3111

Size Price Availability
5mg USD 90  USD100 4-7 Days
10mg USD 162  USD180 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Btk inhibitor 2 (BGB-3111) is a Brutons tyrosine kinase (BTK) inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 431.49
Formula C24H25N5O3
CAS Number 1558036-85-3
Purity >98%
Solubility DMSO: 80 mg/mL
Storage at -20°C
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Tolebrutinib

Tolebrutinib, also known as SAR442168, is a Bruton tyrosine kinase (BTK) inhibitor, with IC50 values of 0.4 nM and 0.7 nM in Ramos B cells and HMC microglia cells, respectively.

Orelabrutinib

Orelabrutinib is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).

Zanubrutinib

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ARQ 531

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Btk inhibitor 2, BGB-3111 supplier, BTK, inhibitors

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