Free shipping on all orders over $ 500

Btk inhibitor 2

Cat. No. M8887
Btk inhibitor 2 Structure


Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 125  USD125 In stock
25mg USD 280  USD280 In stock
50mg USD 470  USD470 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Btk inhibitor 2 (BGB-3111) is a Brutons tyrosine kinase (BTK) inhibitor.

Chemical Information
Molecular Weight 431.49
Formula C24H25N5O3
CAS Number 1558036-85-3
Solubility (25°C) DMSO: 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Ronen Gabizon, et al. A Fast and Clean BTK Inhibitor

[2] Wei Xu, et al. Treatment of relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma with the BTK inhibitor zanubrutinib: phase 2, single-arm, multicenter study

[3] Qiuyun Luo, et al. A Novel BCL-2 Inhibitor APG-2575 Exerts Synthetic Lethality With BTK or MDM2-p53 Inhibitor in Diffuse Large B-Cell Lymphoma

[4] Constantine S Tam, et al. Phase 1 study of the selective BTK inhibitor zanubrutinib in B-cell malignancies and safety and efficacy evaluation in CLL

[5] Xavier Montalban, et al. Placebo-Controlled Trial of an Oral BTK Inhibitor in Multiple Sclerosis

Related BTK Products

NX-2127 is an orally active, potent BTK inhibitor that induces degradation of mutant BTKC481S in cells, as well as inhibits the proliferation of BTKC481S mutant TMD8 cells. In addition, NX-2127 stimulates T cell activation and increases IL-2 production in primary human T cells.


DBt-10 is a potent BTK degrader.


BTK-IN-27 is a BTK inhibitor (IC50: 0.2 nM).


NRX-0492 is an orally active and potent degrader of BTK.

PROTAC BTK Degrader-5

PROTAC BTK degraders-5is a selective BTK degrader with a DC50 value of 7.0 nM in JeKo-1 cells.

Abmole Inhibitor Catalog

Keywords: Btk inhibitor 2, BGB-3111 supplier, BTK, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.