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CNX-774

Cat. No. M2536

All AbMole products are for research use only, cannot be used for human consumption.

CNX-774 Structure
Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 150  USD150 In stock
25mg USD 260  USD260 In stock
50mg USD 480  USD480 In stock
100mg USD 800  USD800 In stock
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Quality Control & Documentation
Biological Activity

CNX-774 is an irreversible, orally active, and highly selective BTK inhibitor with IC50 of <1 nM.

Chemical Information
Molecular Weight 499.5
Formula C26H22FN7O3
CAS Number 1202759-32-7
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jeong-Mi Kim, et al. Bruton's agammaglobulinemia tyrosine kinase (Btk) regulates TPA‑induced breast cancer cell invasion via PLCγ2/PKCβ/NF‑κB/AP‑1‑dependent matrix metalloproteinase‑9 activation

[2] D Smiljkovic, et al. BTK inhibition is a potent approach to block IgE-mediated histamine release in human basophils

[3] Akintunde Akinleye, et al. Ibrutinib and novel BTK inhibitors in clinical development

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Keywords: CNX-774 supplier, BTK, inhibitors, activators

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