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BTK inhibitor 1 (Compound 27)

Cat. No. M20631

All AbMole products are for research use only, cannot be used for human consumption.

BTK inhibitor 1 (Compound 27) Structure

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Quality Control & Documentation
Biological Activity

BTK inhibitor 1 (compound 27) is an inhibitor of BTK with an IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with an IC50 of 2 nM.

Chemical Information
Molecular Weight 474.49
Formula C24H23FN8O2
CAS Number 2230724-66-8
Solubility (25°C) DMSO 95 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Soňa Krajčovičov, et al. Eur J Med Chem. 1,4,6-Trisubstituted imidazo[4,5-c]pyridines as inhibitors of Bruton's tyrosine kinase

[2] Jeffrey A Jones, et al. Lancet Oncol. Venetoclax for chronic lymphocytic leukaemia progressing after ibrutinib: an interim analysis of a multicentre, open-label, phase 2 trial

[3] Sobhana Babu Boga, et al. Bioorg Med Chem Lett. Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis

[4] Xiaolei Gao, et al. Bioorg Med Chem Lett. Discovery of novel BTK inhibitors with carboxylic acids

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UBX-382 is an orally available proteolysis-targeting chimeras (PROTACs) that target BTK to inactivate B-cell receptor signaling.

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N-piperidine Ibrutinib hydrochloride is a reversible Ibrutinib derivative.

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Keywords: BTK inhibitor 1 (Compound 27) supplier, BTK, inhibitors, activators

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