About 30 results found for searched term "NAMI-A" (0.045 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2006 | Safinamide Mesylate | Monoamine Oxidase |
| FCE28073, PNU-151774E, NW-1015 | ||
| Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor. | ||
| M2278 | Bosentan Hydrate | Endothelin Receptor |
| Benzenesulfonamide Hydrate; Ro-47-0203 Hydrate | ||
| Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. | ||
| M2373 | Allylthiourea | Others |
| Thiosinamine; N-Allylthiourea | ||
| Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation. | ||
| M2706 | Flufenamic acid | COX |
| Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator. | ||
| M2817 | Meclofenamate sodium | COX |
| CI 583 ; Meclofenamic acid sodium | ||
| Meclofenamate sodium is a dual COX-1/COX-2 inhibitor with an IC50 of 40 nM and 50 nM, respectively. used in the study of joint and muscle pain, arthritis, and dysmenorrhea. meclofenamate sodium is a non-selective gap-junction blocker and a highly selective inhibitor of adipose and obesity-associated enzyme (FTO) inhibitor. | ||
| M3066 | Thiostrepton | Antibiotic |
| Alaninamide, Bryamycin, Thiactin | ||
| Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. Thiostrepton is a natural cyclic oligopeptide antibiotic, derived from several strains of strepromycetes. | ||
| M3362 | Tolfenamic Acid | COX |
| GEA 6414 | ||
| Tolfenamic Acid is a COX-2 inhibitor, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1. | ||
| M3458 | Chlorpheniramine Maleate | Histamine Receptor |
| Chlorphenamine maleate | ||
| Chlorpheniramine (Chlorpheniramine maleate, Chlorphenamine) is an histamine H1 receptor antagonist with IC50 of 12 nM. | ||
| M4447 | 3-Hydroxy-4-methoxycinnamic-acid | Adrenergic Receptor |
| 3-Hydroxy-4-methoxycinnamic acid | ||
| Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is a kind of cinnamic acid derivative with anti - diabetes activity. Isoferulic acid (3-hydroxy-4-methoxycinnamic acid) binds and activates α 1-adrenergic receptor (IC50=1.4 μM), Enhanced β -endorphin secretion (EC50=52.2 nM) and increased in vitro glucose use. Isoferulic acid also has activity against influenza virus. | ||
| M4602 | p-Coumaric-acid | Metabolite/Endogenous Metabolite |
| trans-4-Hydroxycinnamic acid | ||
| P -Coumaric acid is an isomer of cinnamic acid, which has anti-tumor and anti-mutagenic activities. | ||
| M9202 | α-cyano-4-hydroxy-cinnamic acid | Monocarboxylate Transporter (MCT) |
| ACCA; α-CHCA | ||
| α-Cyano-4-hydroxycinnamic acid (α-CHCA) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. | ||
| M8004 | Phenamil methanesulfonate salt | Sodium Channel |
| Phenamil methanesulfonate is an irreversible inhibitor of amiloride-sensitive Na+ channels; derivative of amiloride. | ||
| M8315 | Ralfinamide mesylate | Others |
| Ralfinamide is a mixed sodium and N-type calcium channel blocker. | ||
| M8782 | NAMI-A | Others |
| NAMI-A is a potent antimetastatic compound in vivo that is exhibits little cytotoxicity towards many cancer cell lines. | ||
| M9086 | NAD+ | Enzymes & Coenzymes |
| β-DPN; β-NAD; Coenzyme 1; Nadide；β-Nicotinamide Adenine Dinucleotide | ||
| NAD+, nicotinamide adenine dinucleotide, is a coenzyme that transfers hydrogen ions and is formed by the coupling of ribosylnicotinamide 5'-diphosphate to adenosine 5'-phosphate via pyrophosphate bonding. NAD+ is the oxidized form of NADH. NAD+ is a coenzyme that is formed by the coupling of ribosylnicotinamide 5'-diphosphate to adenosine 5 '-phosphate coupled by pyrophosphate bonding. | ||
| M9613 | 4-P-PDOT | Melatonin Receptor |
| 4P-PDOT; 4-phenyl-2- propionamidotetralin | ||
| 4-P-PDOT is a MT2-receptor-specific antagonist, it is >300-fold more selective for MT2 than MT1. | ||
| M10075 | (+)-Biotinamidohexanoic acid hydrazide | Others |
| Biotin LC hydrazide | ||
| Biotin LC hydrazide is a long chain protein modification reagent, which can transform periodate-oxidized glycoproteins. | ||
| M10854 | Melflufen hydrochloride | DNA Alkylator/Crosslinker |
| Melphalan flufenamide hydrochloride; L-PAM | ||
| Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide precursor of Melphalan, is an alkylated agent. Melflufen hydrochloride has antitumor activity against multiple myeloma cells and inhibits angiogenesis. Melflufen hydrochloride has irreversible damage to myeloma cell DNA and cytotoxic effects. | ||
| M10974 | 3,4-Dimethoxycinnamic acid | ROS |
| O-Methylferulic acid | ||
| 3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata. 3,4-Dimethoxycinnamic acid exerts an anti-apoptotic effect on L-02 cells through a ROS-mediated signaling pathway. | ||
| M10975 | (E)-3,4-Dimethoxycinnamic acid | ROS |
| (E)-O-Methylferulic acid | ||
| (E)-3,4-Dimethoxycinnamic acid is a lowly active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts an anti-apoptotic effect on L-02 cells through a ROS-mediated signaling pathway. | ||
| M11201 | Nicotinamide riboside | Sirtuin |
| BETA-nicotinamide ribose;Beta-Nicotinamide Riboside | ||
| Nicotinamide riboside is a precursor to nadir with oral activity that increases NAD levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) that enhances oxidative metabolism and prevents metabolic abnormalities induced by a high-fat diet. Nicotinamide riboside can reduce cognitive degradation in transgenic mouse models of Alzheimer's disease. | ||
| M11465 | trans-Cinnamic acid | Antibiotic |
| trans-Cinnamic acid； Phenylacrylic acid, Cinnamylic acid | ||
| Trans-cinnamic acid was A fungicide with A minimum inhibitory concentration (MIC) of 250 μg/mL against A. sobria (SY-AS1). | ||
| M14502 | Deltasonamide 2 (TFA) | PDE |
| Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. | ||
| M16114 | Bryonamide A | Alkaloids |
| Bryonamide A | ||
| M17397 | 3-Hydroxycinnamic acid | Phenylpropanoids |
| 3-Hydroxycinnamic acid | ||
| M17404 | Hydrocinnamic acid | Phenylpropanoids |
| Hydrocinnamic acid | ||
| M18309 | p-Hydroxy-cinnamic acid | Metabolite/Endogenous Metabolite |
| p-Hydroxy-cinnamic acid inhibits platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively. | ||
| M18336 | 2-Methoxycinnamic acid | Tyrosinase |
| 2-Methoxycinnamic acid | ||
| M18338 | 4-Methoxycinnamic acid | Metabolite/Endogenous Metabolite |
| 4-Methoxycinnamic acid | ||
| M18895 | Cinnamic acid | Others |
| Cinnamic acid | ||
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