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Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation. Thiostrepton is a natural cyclic oligopeptide antibiotic, derived from several strains of strepromycetes.
| Molecular Weight | 1664.89 |
| Formula | C72H85N19O18S5 |
| CAS Number | 1393-48-2 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage | -20°C, dry, sealed |
[5] K C Nicolaou. How thiostrepton was made in the laboratory
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