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4-P-PDOT

Cat. No. M9613

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4-P-PDOT Structure
Synonym:

4P-PDOT; 4-phenyl-2- propionamidotetralin

Size Price Availability Quantity
10mg USD 140  USD140 In stock
50mg USD 422  USD422 In stock
100mg USD 608  USD608 In stock
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Biological Activity

4-P-PDOT is a MT2-receptor-specific antagonist, it is >300-fold more selective for MT2 than MT1. 4-P-PDOT significantly counteracts Melatonin-mediated antioxidant effects (GSH/GSSG ratio, phospho-ERK, Nrf2 nuclear translocation, Nrf2 DNA-binding activity). In CHO-MT2 cells, 4-P-PDOT is an agonist, producing a concentration-dependent inhibition of forskolin stimulated cyclic AMP, with a pEC50 value of 8.72 and intrinsic activity of 0.86. In vivo, 4-P-PDOT (0.5-1.0 mg/kg; intravenous injection) treatment on klotho mutant mice significantly reverses antioxidant effects mediated by Melatonin.

Chemical Information
Molecular Weight 279.38
Formula C19H21NO
CAS Number 134865-74-0
Form Solid
Solubility (25°C) DMSO ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Eun-Joo Shin, et al. Int J Neuropsychopharmacol. Melatonin Attenuates Memory Impairment Induced by Klotho Gene Deficiency via Interactive Signaling Between MT2 Receptor, ERK, and Nrf2-related Antioxidant Potential

[2] M L Dubocovich, et al. Naunyn Schmiedebergs Arch Pharmacol. Melatonin Receptor Antagonists That Differentiate Between the Human Mel1a and Mel1b Recombinant Subtypes Are Used to Assess the Pharmacological Profile of the Rabbit Retina ML1 Presynaptic Heteroreceptor

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Keywords: 4-P-PDOT, 4P-PDOT; 4-phenyl-2- propionamidotetralin supplier, Melatonin Receptor, inhibitors, activators

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