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Chlorpheniramine, a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
| Cell Experiment | |
|---|---|
| Cell lines | MCF-7, MDA-MB 231, and Ehrlich |
| Preparation method | Exposing cells to various concentrations of Chlorpheniramine for 48 hours. Cells are washed, detached, and counted with a Coulter counter to determine cell growth. |
| Concentrations | Dissolved in water, final concentrations ~500 μM |
| Incubation time | 48 hours |
| Animal Experiment | |
|---|---|
| Animal models | Male NC/Nga mice, male ICR mice and female BALB/c mice with atopic dermatitis |
| Formulation | Suspended in 1% (v/v) Tween 80 |
| Dosages | 10 mg/kg |
| Administration | Orally |
| Molecular Weight | 390.86 |
| Formula | C16H19ClN2.C4H4O4 |
| CAS Number | 113-92-8 |
| Solubility (25°C) | DMSO 70 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Histamine Receptor Products |
|---|
| Dimethindene
Dimethindene is a potent, selective histamine H1 antagonist. |
| ABT-288
ABT-288 is a competitive, potent and selective histamine H3 receptor (H3R) antagonist. |
| A-349821
A-349821 is a histamine H3 receptor antagonist characterized as a radioligand ([3H]-A-349821) for in vivo receptor occupancy assessment. |
| Betazole
Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active histamine H2 receptor agonist. |
| Tiotidine
Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium). |
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