About 20 results found for searched term "Lipid A9" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M57782 | Lipid A9 | Others |
| Lipid A9 | ||
| M4228 | Neferine | NF-κB |
| (-)-Neferine | ||
| Neferine is a bisbenzylisoquinoline alkaloid extracted from Plumbago officinalis, which reduces lipid accumulation and promotes β-oxidation through activation of the AMPK pathway in hepatocytes, and possesses anti-inflammatory, antioxidant, and antipulmonary fibrosis activities. In addition, Neferine potently inhibits NF-κB activation.The affinity Kd value of Neferine for ABCB1 is 0.659 μM.It can be used in studies related to non-alcoholic steatohepatitis (NASH). | ||
| M6401 | Acifran | Others |
| Acifran is a hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors. | ||
| M7822 | Gemfibrozil | PPAR |
| 吉非罗齐; CI-719 | ||
| Gemzil is a PPAR-α activator, which is a lipid-lowering agent. Gemfibrozil is also a nonselective inhibitor of P450, with Ki values of 5.8, 24,69 and 82 μM for CYP2C9, 2C19, 2C8 and 1A2, respectively. | ||
| M9155 | Autophinib | Autophagy |
| Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin with IC50 values of 90 and 40 nM, targeting the lipid kinase VPS34 with IC50 value of 19 nM in vitro. | ||
| M13397 | Peretinoin | RAR/RXR |
| NIK333 | ||
| Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with EC50 of 9 μM. | ||
| M21202 | Recombinant Human Lipocalin-2/NGAL/LCN2 (E. coli, C-6His) | Cytokines and Growth Factors |
| Neutrophil gelatinase-associated lipocalin; NGAL | ||
| Human neutrophil gelatinase-associated lipid transport protein (Lipocalin-2/NGAL/LCN2) is produced by the E. coli expression system and the target gene encoding Gln21-Gly198 has a 6His tag at the C-terminus.Protein number: P80188 | ||
| M21539 | TC LPA5 4 | LPL Receptor |
| TC LPA5 4 is a specific non-lipid LPA5 (GPR92) antagonist (IC50=0.8 μM in LPA5-RH7777 cells). Shows selectivity for LPA5 against 80 other screening targets.TC LPA5 4 was shown to inhibit LPA-induced aggregation of isolated human platelets.TC LPA5 4 inhibits proliferation and migration of thyroid cancer cells. | ||
| M27669 | E1231 | Sirtuin |
| 1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one | ||
| E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (KD=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases. | ||
| M28693 | UCB9608 | PI3K |
| UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM, selective over PI3KC2 α, β, and γ lipid kinases. UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent. | ||
| M29142 | PIP4K-IN-a131 | Others |
| PIP4K-IN-a131 is PIP4K lipid kinases inhibitor, with IC50s of 1.9 µM and 0.6 µM for purified PIP4K2A and PIP4Ks, respectively. PIP4K-IN-a131 exhibits cancer-selective lethality via dual blockade of the lipid kinase PIP4Ks and mitotic pathways. | ||
| M29282 | KRP-297 | PPAR |
| MK-0767 | ||
| KRP-297 is a PPARα and PPARγ agonist potentially for the research of type 2 diabetes and dyslipidemia. KRP-297 restores reduced lipid oxidation, and inhibits of enhanced lipogenesis and triglyceride accumulation in the liver. | ||
| M29325 | ABDP 581/591 C11 | Fluorescent Dye |
| ABDP C11 | ||
| ABDP 581/591 C11 (same as BODIPY 581/591 C11) is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. ABDP 581/591 C11 (same as BODIPY 581/591 C11) can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. ABDP 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type). | ||
| M30259 | (E)-Ferulic acid | Wnt/beta-catenin |
| (E)-Coniferic acid | ||
| (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. | ||
| M40827 | Laurdan | Fluorescent Dye |
| Laurdan is a membrane-permeable fluorescent probe that is spectrally sensitive to the phospholipid phase of cell membranes to which it binds, and can be used for the identification of phospholipid phases, the absorption wavelength of Laurdan is 340-380nm and the emission wavelength is 440-490nm. | ||
| M49798 | 80-O14B | Liposome |
| 80-O14B is a cationic lipid-like compound that can be used for CRISPR/Cas9 delivery. | ||
| M49807 | TCL053 | Liposome |
| TCL053 is an ionizable lipid that can be used to efficiently introduce active ingredients, especially nucleic acids, into cells. In addition, TCL053 is capable of forming lipid nanoparticles (LNPs) with dipalmitoylphosphatidylcholine (DPPC), polyethylene glycol dimyristoylglycerol (PEG-DMG), and cholesterol, which can be used to deliver Cas9 mRNA and sgRNA into skeletal muscle. | ||
| M49815 | BAMEA-O16B | Liposome |
| BAMEA-O16B is a lipid nanoparticle that binds disulfide bonds and can efficiently deliver Cas9 mRNA and sgRNA into cells while releasing RNA for genome editing in response to intracellular reducing environments.BAMEA-O16B can be used for gene editing research. | ||
| M49819 | N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide | Liposome |
| N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide is an analog of TT3, an ionizable lipid-like material used for mRNA and CRISPR/Cas9 delivery. | ||
| M58560 | Glucocerebrosides (Soy) | Others |
| Glucosylceramide (GluCer) is a major sphingolipid of plant tissue and, thus, abundant in nature and in dietary food sources. Soybean GluCer was comprised primarily (>98%) of ceramide with 4,8-sphingadiene (d18:2(delta4,delta8)) and alpha- hydroxypalmitic acid (h16:0); the remainder had the same backbone with h18:0, h20:0, h22:0 and h24:0 fatty acids. | ||
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