Free shipping on all orders over $ 500

TC LPA5 4

Cat. No. M21539
TC LPA5 4  Structure
Size Price Availability Quantity
10mg USD 300  USD300 In stock
25mg USD 675  USD675 In stock
50mg USD 1160  USD1160 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

TC LPA5 4 is a specific non-lipid LPA5 (GPR92) antagonist (IC50=0.8 μM in LPA5-RH7777 cells). Shows selectivity for LPA5 against 80 other screening targets.TC LPA5 4 was shown to inhibit LPA-induced aggregation of isolated human platelets.TC LPA5 4 inhibits proliferation and migration of thyroid cancer cells.

Chemical Information
Molecular Weight 410.89
Formula C23H23ClN2O3
CAS Number 1393814-38-4
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 2-8℃, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Related LPL Receptor Products
BMS-986278

BMS-986278 is a potent LPA1 antagonist with a Kb of 6.9 nM.

SAR247799

The S1P1 agonist SAR247799 is a biased agonist of the S1P1 sphingosine receptor, preferentially activating G protein signaling over the β-arrestin and internalization pathways.

GLPG2938

GLPG2938 is a potent and selective S1P2 antagonist.GLPG2938 can be used in the study of idiopathic pulmonary fibrosis (IPF).

LPA2 antagonist 1

LPA2 antagonist 1 is a LPA2 antagonist with an IC50 of 17 nM.

FTY720 (S)-Phosphate

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

  Catalog
Abmole Inhibitor Catalog




Keywords: TC LPA5 4 supplier, LPL Receptor, inhibitors, activators

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.