| Cat.No. | Name | Information |
|---|---|---|
| M55044 | Ceranib-2 | Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhibits anticancer activity. |
| M30766 | CYM-5478 | CYM-5478 is a potent and highly selective S1P2 agonist with an EC50 of 119 nM in a TGFα-shedding assay. CYM-5478 protects neural-derived cell lines against Cisplatin toxicity. |
| M29857 | CAY10444 | CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca2+ in HeLa cells expressing S1P3 receptors. |
| M29816 | SLF1081851 | SLF1081851 is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 plays a key role in development and immune system. |
| M28232 | CYM50179 | CYM50179 (compound 22n) is a potent and selective S1P4-R (Sphingosine-1-phosphate4 receptor) agonist with an EC50 of 46 nM. |
| M21539 | TC LPA5 4 | TC LPA5 4 is a specific non-lipid LPA5 (GPR92) antagonist (IC50=0.8 μM in LPA5-RH7777 cells). Shows selectivity for LPA5 against 80 other screening targets.TC LPA5 4 was shown to inhibit LPA-induced aggregation of isolated human platelets.TC LPA5 4 inhibits proliferation and migration of thyroid cancer cells. |
| M21207 | BMS-986278 | BMS-986278 is a potentially first-in-class, potent, small molecule LPA1 antagonist with a Kb of 6.9 nM that can be used in studies related to lung injury and pulmonary fibrosis. |
| M14002 | LPA2 antagonist 1 | LPA2 antagonist 1 is a LPA2 antagonist with an IC50 of 17 nM. |
| M13999 | BMS-986020 sodium | BMS-986020 sodium is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist. |
| M11160 | 1-Oleoyl lysophosphatidic acid sodium | 1-Oleoyl Lysophosphatidic acid (1-Oleoyl-Sn-glycero-3-phosphate) sodium is an effective bioactive phospholipid, which is an LPA receptor activator. 1-oleoyl Lysophosphatidic acid sodium promotes mitosis by inducing DNA synthesis. |
| M8994 | AM095 free acid | AM095 free acid is a potent LPA1 receptor antagonist which inhibited GTPγS binding to CHO cell membranes overexpressing recombinant human or mouse LPA1 with IC50 values of 0.98 and 0.73 μM, respectively. |
| M8993 | BMS-986020 | BMS-986020 (also known as AM152) is a potent and selective LPA1 antagonist. |
| M8992 | AM966 | AM966 is a potent, selective and orally active LPA(1) receptor antagonist which inhibits lung fibrosis in the mouse bleomycin model. |
| M7674 | AM095 sodium | AM095 is a potent and selective, orally bioavailable antagonist of lysophosphatidic acid receptor1 (LPA1). |
| M6782 | H2L5186303 | H2L5186303 is a potent and selective LPA2 receptor antagonist with an IC50 of 9 nM. |
| M6159 | GSK-2018682 | This compound belongs to the class of organic compounds known as n-alkylindoles. These are compounds containing an indole moiety that carries an alkyl chain at the 1-position. |
| M2792 | Ki16198 | Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activity at LPA4, LPA5, LPA6. |
| M2213 | Ki16425 | Ki16425 is a LPA receptor antagonist with Ki values of 0.34, 6.5 and 0.93 μM for the human LPA1, LPA2 and LPA3 receptors, respectively. |
| M56243 | CS-2100 | CS-2100 is a potent, selective, orally active and S1P3-sparing S1P1 agonist with an EC50 of 4.0 nM for human S1P1. |
| M56242 | CYM50308 | CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. |
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