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LPL Receptor Lysophospholipid receptor

Cat.No.  Name Information
M55044 Ceranib-2 Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhibits anticancer activity.
M29857 CAY10444 CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca2+ in HeLa cells expressing S1P3 receptors.
M29816 SLF1081851  SLF1081851 is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 plays a key role in development and immune system.
M28232 CYM50179  CYM50179 (compound 22n) is a potent and selective S1P4-R (Sphingosine-1-phosphate4 receptor) agonist with an EC50 of 46 nM.
M21539 TC LPA5 4 TC LPA5 4 is a specific non-lipid LPA5 (GPR92) antagonist (IC50=0.8 μM in LPA5-RH7777 cells). Shows selectivity for LPA5 against 80 other screening targets.TC LPA5 4 was shown to inhibit LPA-induced aggregation of isolated human platelets.TC LPA5 4 inhibits proliferation and migration of thyroid cancer cells.
M21207 BMS-986278 BMS-986278 is a potentially first-in-class, potent, small molecule LPA1 antagonist with a Kb of 6.9 nM that can be used in studies related to lung injury and pulmonary fibrosis.
M14002 LPA2 antagonist 1 LPA2 antagonist 1 is a LPA2 antagonist with an IC50 of 17 nM.
M13999 BMS-986020 sodium BMS-986020 sodium is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist.
M11160 1-Oleoyl lysophosphatidic acid sodium 1-Oleoyl Lysophosphatidic acid (1-Oleoyl-Sn-glycero-3-phosphate) sodium is an effective bioactive phospholipid, which is an LPA receptor activator. 1-oleoyl Lysophosphatidic acid sodium promotes mitosis by inducing DNA synthesis.
M8994 AM095 free acid AM095 free acid is a potent LPA1 receptor antagonist which inhibited GTPγS binding to CHO cell membranes overexpressing recombinant human or mouse LPA1 with IC50 values of 0.98 and 0.73 μM, respectively.
M8993 BMS-986020 BMS-986020 (also known as AM152) is a potent and selective LPA1 antagonist.
M8992 AM966 AM966 is a potent, selective and orally active LPA(1) receptor antagonist which inhibits lung fibrosis in the mouse bleomycin model.
M7674 AM095 sodium AM095 is a potent and selective, orally bioavailable antagonist of lysophosphatidic acid receptor1 (LPA1).
M6782 H2L5186303 H2L5186303 is a potent and selective LPA2 receptor antagonist with an IC50 of 9 nM.
M6159 GSK-2018682 This compound belongs to the class of organic compounds known as n-alkylindoles. These are compounds containing an indole moiety that carries an alkyl chain at the 1-position.
M2792 Ki16198 Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activity at LPA4, LPA5, LPA6.
M2213 Ki16425 Ki16425 is a LPA receptor antagonist with Ki values of 0.34, 6.5 and 0.93 μM for the human LPA1, LPA2 and LPA3 receptors, respectively.
M50181 BMS-986234 BMS-986234 is a lysophosphatidic acid receptor-1 (LPA1) antagonist with a Kb value of 2.8 ± 0.4 nM.
M49441 BMS-986337 BMS-986337 is a lysophosphatidic acid receptor (LPAR1) antagonist for studies related to pulmonary fibrosis.
M49410 DJS-002 DJS-002 is an LPA1 receptor antagonist that may be used in studies related to idiopathic pulmonary fibrosis (IPF).

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