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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M14000 | Fingolimod | Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant. |
| M21539 | TC LPA5 4 | TC LPA5 4 is a specific non-lipid LPA5 (GPR92) antagonist (IC50=0.8 μM in LPA5-RH7777 cells). Shows selectivity for LPA5 against 80 other screening targets.TC LPA5 4 was shown to inhibit LPA-induced aggregation of isolated human platelets.TC LPA5 4 inhibits proliferation and migration of thyroid cancer cells. |
| M21207 | BMS-986278 | BMS-986278 is a potent LPA1 antagonist with a Kb of 6.9 nM. |
| M21193 | SAR247799 | The S1P1 agonist SAR247799 is a biased agonist of the S1P1 sphingosine receptor, preferentially activating G protein signaling over the β-arrestin and internalization pathways. |
| M21147 | GLPG2938 | GLPG2938 is a potent and selective S1P2 antagonist.GLPG2938 can be used in the study of idiopathic pulmonary fibrosis (IPF). |
| M14002 | LPA2 antagonist 1 | LPA2 antagonist 1 is a LPA2 antagonist with an IC50 of 17 nM. |
| M14001 | FTY720 (S)-Phosphate | FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. |
| M14000 | Fingolimod | Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant. |
| M13999 | BMS-986020 sodium | BMS-986020 sodium is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist. |
| M13998 | ASP-4058 | ASP-4058 is a next-generation, selective and oral bioactive agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. |
| M11160 | 1-Oleoyl lysophosphatidic acid sodium | 1-Oleoyl Lysophosphatidic acid (1-Oleoyl-Sn-glycero-3-phosphate) sodium is an effective bioactive phospholipid, which is an LPA receptor activator. 1-oleoyl Lysophosphatidic acid sodium promotes mitosis by inducing DNA synthesis. |
| M8994 | AM095 free acid | AM095 free acid is a potent LPA1 receptor antagonist which inhibited GTPγS binding to CHO cell membranes overexpressing recombinant human or mouse LPA1 with IC50 values of 0.98 and 0.73 μM, respectively. |
| M8993 | BMS-986020 | BMS-986020 (also known as AM152) is a potent and selective LPA1 antagonist. |
| M8992 | AM966 | AM966 is a potent, selective and orally active LPA(1) receptor antagonist which inhibits lung fibrosis in the mouse bleomycin model. |
| M7674 | AM095 sodium | AM095 is a potent and selective, orally bioavailable antagonist of lysophosphatidic acid receptor1 (LPA1). |
| M6965 | MK-571 sodium salt | MK-571 sodium salt is a selective, orally active CysLT1 receptor antagonist. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). |
| M2213 | Ki16425 | Ki16425 is a LPA receptor antagonist with Ki values of 0.34, 6.5 and 0.93 μM for the human LPA1, LPA2 and LPA3 receptors, respectively. |
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