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BMS-986278 is a potentially first-in-class, potent, small molecule LPA1 antagonist with a Kb of 6.9 nM that can be used in studies related to lung injury and pulmonary fibrosis.
| Molecular Weight | 445.51 |
| Formula | C22H31N5O5 |
| CAS Number | 2170126-74-4 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related LPL Receptor Products |
|---|
| CS-2100
CS-2100 is a potent, selective, orally active and S1P3-sparing S1P1 agonist with an EC50 of 4.0 nM for human S1P1. |
| CYM50308
CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. |
| ONO-9780307
ONO-9780307 is a specific synthetic LPA1 (lysophosphatidic acid receptor 1) antagonist with an IC50 value of 2.7 nM. |
| ACT-1016-0707
ACT-1016-0707 is an orally active and selective LPA1 receptor antagonist. |
| CYM5442 hydrochloride
CYM5442 hydrochloride is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC50 of 1.35 nM. |
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