LPA2 antagonist 1 is a LPA2 antagonist with an IC50 of 17 nM.
|Solubility (25°C)||DMF ≥ 90 mg/mL
DMSO ≥ 90 mg/mL
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Rami Lee, et al. Effect of the Gintonin-Enriched Fraction on Glucagon-Like-Protein-1 Release
 Stephan Hasse, et al. Interplay between LPA2 and LPA3 in LPA-mediated phosphatidylserine cell surface exposure and extracellular vesicles release by erythrocytes
 Hui Geng, et al. Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion
 Kazue Hisaoka-Nakashima, et al. Lysophosphatidic acid induces thrombospondin-1 production in primary cultured rat cortical astrocytes
 Ioanna Plastira, et al. 1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype
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