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LPA2 antagonist 1

Cat. No. M14002
LPA2 antagonist 1 Structure
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5mg USD 425  USD425 4-7 Days
10mg USD 625  USD625 4-7 Days
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Biological Activity

LPA2 antagonist 1 is a LPA2 antagonist with an IC50 of 17 nM.

Chemical Information
Molecular Weight 500.46
CAS Number 1017606-66-4
Solubility (25°C) DMF ≥ 90 mg/mL
DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rami Lee, et al. Effect of the Gintonin-Enriched Fraction on Glucagon-Like-Protein-1 Release

[2] Stephan Hasse, et al. Interplay between LPA2 and LPA3 in LPA-mediated phosphatidylserine cell surface exposure and extracellular vesicles release by erythrocytes

[3] Hui Geng, et al. Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion

[4] Kazue Hisaoka-Nakashima, et al. Lysophosphatidic acid induces thrombospondin-1 production in primary cultured rat cortical astrocytes

[5] Ioanna Plastira, et al. 1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype

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