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Ceranib-2

Cat. No. M55044

All AbMole products are for research use only, cannot be used for human consumption.

Ceranib-2 Structure
Size Price Availability
5mg USD 60  USD60 4-7 Days
10mg USD 110  USD110 4-7 Days
25mg USD 230  USD230 4-7 Days
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Quality Control & Documentation
Biological Activity

Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhibits anticancer activity.

Ceranib-2 (10 nM-10 µM; 72 hours; SKOV3 cells) treatment inhibits cell proliferation and/or survival with an IC50 value of 0.73 μM.

Ceranib-2 (20-50 mg/kg; intraperitoneal injection; daily for 5 days per week; for 3 weeks; female Balb/c mice) treatment delays tumor growth in a syngeneic tumor model without hematologic suppression or overt signs of toxicity.

Chemical Information
Molecular Weight 381.42
Formula C25H19NO3
CAS Number 1402830-75-4
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
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Keywords: Ceranib-2 supplier, LPL Receptor, inhibitors, activators

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