TCL053 is an ionizable lipid that can be used to efficiently introduce active ingredients, especially nucleic acids, into cells. In addition, TCL053 is capable of forming lipid nanoparticles (LNPs) with dipalmitoylphosphatidylcholine (DPPC), polyethylene glycol dimyristoylglycerol (PEG-DMG), and cholesterol, which can be used to deliver Cas9 mRNA and sgRNA into skeletal muscle.
| Molecular Weight | 874.32 |
| Formula | C53H95NO8 |
| CAS Number | 2361162-70-9 |
| Form | Liquid |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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