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Cat. No. M14954
DLinDMA Structure
Size Price Availability Quantity
50mg USD 150  USD150 In stock
100mg USD 260  USD260 In stock
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Quality Control & Documentation
Biological Activity

DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery.

Chemical Information
Molecular Weight 616.06
CAS Number 871258-12-7
Form Liquid
Solubility (25°C) Ethanol ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Hari Priya Vemana, et al. A novel gene therapy for neurodegenerative Lafora disease via EPM2A-loaded DLinDMA lipoplexes

[2] Paulo J C Lin, et al. Influence of cationic lipid composition on uptake and intracellular processing of lipid nanoparticle formulations of siRNA

[3] Genc Basha, et al. Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells

[4] Sean C Semple, et al. Rational design of cationic lipids for siRNA delivery

[5] James Heyes, et al. Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids

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Keywords: DLinDMA supplier, Liposome, inhibitors, activators

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