DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery.
Molecular Weight | 616.06 |
CAS Number | 871258-12-7 |
Form | Liquid |
Solubility (25°C) | Ethanol ≥ 90 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] Sean C Semple, et al. Rational design of cationic lipids for siRNA delivery
Related Liposome Products |
---|
LNP Lipid-7
1LNP Lipid-7 is a lipid. |
LNP Lipid-4
LNP Lipid-4 is a lipid compound. |
DLin-M-C4-DMA
DLin-M-C4-DMA is a cationic lipid. |
ALC-0315 analogue-1
ALC-0315 analogue-1 is a cationic lipid. |
VC1052
VC1052 is the component of Vaxfectin. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.