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Cat. No. M9382
DLin-MC3-DMA Structure

MC-3; RV-28; D-Lin-MC3-DMA

Size Price Availability Quantity
10mg USD 200  USD200 In stock
25mg USD 350  USD350 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

DLin-MC3-DMA is the most potent cationic lipid that has been synthesized for lipid nanoparticles (LNPs) to deliver the siRNA.

Chemical Information
Molecular Weight 642.09
Formula C43H79NO2
CAS Number 1224606-06-7
Solubility (25°C) DMSO 90 mg/mL
Ethanol 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: DLin-MC3-DMA, MC-3; RV-28; D-Lin-MC3-DMA supplier, Liposome, inhibitors, activators

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