DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6), produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies. DLin-KC2-DMA (24 h) exhibits high uptake into macrophages and dendritic cells. DLin-KC2-DMA efficiently promotes release of encapsulated siRNA into the cytosol following uptake via the endocytotic pathway. DLin-KC2-DMA displays almost no toxicity in primary APCs.
Molecular Weight | 642.09 |
Formula | C43H79NO2 |
CAS Number | 1190197-97-7 |
Form | Liquid |
Solubility (25°C) | DMSO 100 mg/mL Ethanol 100 mg/mL |
Storage | -20°C, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] Sean C Semple, et al. Nat Biotechnol. Rational design of cationic lipids for siRNA delivery
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