About 18 results found for searched term "Keap1-Nrf2" (0.117 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M14593 | Keap1-Nrf2-IN-1 | Keap1-Nrf2 |
| Keap1-Nrf2-IN-1 is a Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor erythroid 2-related factor 2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. | ||
| M42729 | Keap1-Nrf2-IN-15 | Keap1-Nrf2 |
| Keap1-Nrf2-IN-15 is a potent Keap1-Nrf2 protein-protein interaction inhibitor with IC50s of 77 nM and 2.5 nM in FP assay and TR-FRET assay, respectively. | ||
| M42735 | Keap1-Nrf2-IN-16 | Keap1-Nrf2 |
| Keap1-Nrf2-IN-16 is a biological active peptide. | ||
| M52371 | Keap1-Nrf2 probe | Keap1-Nrf2 |
| Keap1-Nrf2 probe is a fluorescent Keap1-Nrf2 probe. | ||
| M3988 | Sulforaphane | Keap1-Nrf2 |
| SFN | ||
| Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Sulforaphane (SFN) extracted from broccoli sprout is an agent with potent anti-oxidant and anti-inflammatory activity. | ||
| M6976 | ML 334 | Keap1-Nrf2 |
| LH601A; ML334 | ||
| ML334 (LH601A) is a inhibitor of Keap1- Nrf2 interaction. | ||
| M8348 | 2-HBA (HBB2) | Caspase |
| HBB2 | ||
| 2-HBA (HBB2) is an inducer of the KEAP1/NRF2/ARE pathway that reacts with sulfhydryl groups. | ||
| M8733 | K67 | Keap1-Nrf2 |
| K-67 | ||
| K67 is a specific inhibitor against the interaction between KEAP1 (Kelch-like ECH-associated protein 1) DC (double glycine repeat and C-terminal region) domain and S349-phosphorylated (human Ser349, mouse Ser351) KIR (Keap1-interacting region) of p62/SQSTM1, thereby preventing phospho-p62 from blocking KEAP1-DC and NRF2 (nuclear factor erythroid 2-related factor 2) DLGex motif association. | ||
| M8767 | MIND4-17 | Others |
| MIND4-17 is a potent NRF2 (nuclear factor erythroid 2-related factor 2) activator that covalently modifies a critical stress-sensor cysteine (C151) in the BTB domain of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEAP1), the primary negative regulator of NRF2. | ||
| M14594 | KI696 | Keap1-Nrf2 |
| KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of the KEAP1/NRF2 interaction. | ||
| M18767 | L-Sulforaphane | Keap1-Nrf2 |
| L-Sulforaphane is a highly potent inducer of the Keap1/Nrf2/ARE pathway. | ||
| M25384 | Recombinant Human KEAP1 Protein (Baculovirus-Insect, His & GST Tag) | Cytokines and Growth Factors |
| Kelch-like ECH-associated protein 1; INRF2 | ||
| Kelch-like ECH-associated protein 1 (KEAP1) is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB (POZ) domain, and six Kelch repeats. KEAP1 is a key regulator of the NRF2 transcription factor, which transactivates the antioxidant response element (ARE) and upregulates numerous proteins involved in antioxidant defense. | ||
| M25383 | Recombinant Human KEAP1 Protein (Baculovirus-Insect) | Cytokines and Growth Factors |
| Kelch-like ECH-associated protein 1; INRF2 | ||
| Kelch-like ECH-associated protein 1 (KEAP1) is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB (POZ) domain, and six Kelch repeats. KEAP1 is a key regulator of the NRF2 transcription factor, which transactivates the antioxidant response element (ARE) and upregulates numerous proteins involved in antioxidant defense. | ||
| M27939 | Dibenzoylmethane | Keap1-Nrf2 |
| Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2. | ||
| M28606 | CPUY192018 | Others |
| CPUY192018 is a potent Keap1-Nrf2-ARE inhibitor with an IC50 of 0.63 µM. CPUY192018 exhibits induction of Nrf2-dependent gene NQO1 at 100 µM. | ||
| M30231 | Tricetin | Apoptosis |
| Tricetin is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway. | ||
| M31251 | CBR-470-1 | Keap1-Nrf2 |
| CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade. | ||
| M50196 | BAY-3605349 | Keap1-Nrf2 |
| VVD-130037 | ||
| BAY-3605349 is an orally active Kelch-like ECH-associated protein 1 (KEAP1) activator as well as Nrf2 inhibitor for tumor-related studies. | ||
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