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CBR-470-1 

Cat. No. M31251

All AbMole products are for research use only, cannot be used for human consumption.

CBR-470-1  Structure

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Quality Control & Documentation
Biological Activity

CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade.

Chemical Information
Molecular Weight 365.9
Formula C14H20ClNO4S2
CAS Number 2416095-06-0
Form Solid
Solubility (25°C) DMSO >100 mg/mL (Need ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hua Liu, et al. Neuroscience. Downregulated Phosphoglycerate Kinase 1 Attenuates Cerebral Ischemia-Reperfusion Injury by Reversing Neuroinflammation and Oxidative Stress through the Nuclear Factor Erythroid 2 Related Factor 2/ARE Pathway

[2] Jeyun Jo, et al. Bioorg Chem. Discovery and SAR studies of 3-amino-4-(phenylsulfonyl)tetrahydrothiophene 1,1-dioxides as non-electrophilic antioxidant response element (ARE) activators

[3] Jinyu Zheng, et al. Aging (Albany NY). PGK1 inhibitor CBR-470-1 protects neuronal cells from MPP+

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  Catalog
Abmole Inhibitor Catalog




Keywords: CBR-470-1  supplier, Keap1-Nrf2, inhibitors, activators

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