About 31 results found for searched term "IPA-3" (0.097 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2775 | IPA-3 | Others |
| IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6). | ||
| M25501 | 12-Dipalmitoyl-sn-glycero-3-PS sodium salt | Cell Transfection |
| 12-Dipalmitoyl-sn-glycero-3-PS sodium salt is an anionic diacyl phospholipid, a lipid component in cell membrane. 12-Dipalmitoyl-sn-glycero-3-PS sodium salt can be use in the preparation of catanionic vesicles and liposome. | ||
| M49793 | DPPG sodium | Liposome |
| 1,2-Dipalmitoyl-sn-glycero-3-PG sodium | ||
| DPPG sodium is a phospholipid containing long chain (16:0) palmitic acid inserted in the sn-1 and sn-2 positions.DPPG sodium can be used to prepare micelles, liposomes and other types of artificial membranes. | ||
| M4975 | Cevipabulin | Microtubule |
| TTI-237 | ||
| Cevipabulin(TTI-237) is a novel, potent, synthetic small molecule, inhibits binding of vinblastine at the Vinca alkaloid site of the αβ-tubulin heterodimer. | ||
| M5855 | Rilapladib | Phospholipase |
| SB 659032 | ||
| Rilapladib (SB 659032) is a selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 230 pM. Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist. | ||
| M6705 | EIPA | TRP Channel |
| L593754; MH 12-43; Ethylisopropylamiloride | ||
| EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). | ||
| M6853 | JW 642 | MAGL |
| Jw642 is a highly effective selective monoacylglycerol lipase (MAGL) inhibitor with IC50 of 7.6 nM, 14 nM and 3.7 nM in mouse, rat and human meninges, respectively. | ||
| M7160 | Pristimerin | Antibiotic |
| Celastrol methyl ester | ||
| Pristimerin is a highly reversible monacylglycerol lipase (MGL) inhibitor with an IC50 value of 93 nM. | ||
| M7177 | Quinine hydrochloride | Potassium Channel |
| Quinine hydrochloride is the hydrochloride form of Quinine, an alkaloid extracted from the bark of the cinchona tree, with antimalarial and antitumor activities, and an IC50 value of 60 ng/mL against P. falciparum strains passou and 107.8 ng/mL against P. falciparum strain 3CD7, respectively, and an inhibitor of potassium channels. Quinine hydrochloride is also a potassium channel inhibitor that inhibits voltage pulse-induced MT mSlo3 (KCa5.1) channel +100 mV currents, with an IC50 value of 169 μM. In addition, Quinine hydrochloride binds to purine nucleoside phosphorylase (PfNP) and PfNP with low nanomolar affinity. nucleoside phosphorylase (PfPNP) with low nanomolar affinity. | ||
| M8168 | sPLA2 inhibitor | Phospholipase |
| Secretory phospholipase A2 inhibitor blocks the activation of NF-κB, Akt, p38 MAPK and ERK pathways. | ||
| M9637 | RIPA-56 | RIPK |
| RIPA56 | ||
| RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM. | ||
| M10015 | Recombinant Mouse IL-6 Protein (CHO, C-His) | Recombinant Proteins |
| Interleukin-6; BSF-2; IFN-b2 | ||
| Interleukin-6 (IL-6), also known as BSF-2, CDF and IFNB2, is a pleiotropic cytokine that participates in both pro-inflammatory and anti-inflammatory responses. Measured in a bioassay using 7TD1 cells, the ED50 is < 3.0 pg/ml. | ||
| M10191 | Vipadenant | Adenosine Receptor |
| BIIB014; CEB-4520 | ||
| Vipadenant, also known as BIIB014, CEB-4520, is a potent, selective and orally available adenosine A2A receptor antagonist with Ki of 1.3 nM. | ||
| M10330 | Teriparatide acetate | Others |
| hPTH (1-34) acetate; Parathar acetate | ||
| Teriparatide acetate is a PHT agonist, with an IC50 of 2 nM in HEK293 cells. | ||
| M13413 | JNJ-42226314 | MAGL |
| JNJ-42226314 is a competitive, highly selective and reversible inhibitor of non-covalent monoacylglycerol lipase (MAGL). The IC50s of JNJ-42226314 against human Hela cells, human PBMC, mouse brain and rat brain were 1.13 nM, 1.88 nM, 0.67 nM and 0.97 nM, respectively. | ||
| M13470 | LL-37, human acetate | Antibiotic |
| LL-37, human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human acetate could help protect the cornea from infection and modulates wound healing. | ||
| M13471 | LL-37, human TFA | Antibiotic |
| LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human TFA could help protect the cornea from infection and modulates wound healing. | ||
| M13689 | Cevipabulin fumarate | Microtubule |
| TTI-237 fumarate | ||
| Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound and inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line. | ||
| M14045 | Selexipag | Prostaglandin Receptor |
| NS-304; ACT-293987 | ||
| Selexipag (NS-304) is the methanesulfonamide precursor compound of ACT-333679 and an orally effective prostacyclin (PGI2) receptor agonist. It can be used in studies related to pulmonary arterial hypertension. | ||
| M14278 | EIPA hydrochloride | TRP Channel |
| L593754 hydrochloride; MH 12-43 hydrochloride | ||
| EIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. | ||
| M14784 | Teriparatide | Others |
| Human parathyroid hormone-(1-34); hPTH (1-34) | ||
| Teriparatide (Human parathyroid hormone-(1-34)) is a PHT agonist, with an IC50 of 2 nM in HEK293 cells. | ||
| M17865 | Euphol | Triterpenoids |
| Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). | ||
| M20785 | Ledipasvir acetone | Anti-infection |
| GS-5885 acetone | ||
| Ledipasvir (GS-5885) acetone is the active ingredient of Ledipasvir. Ledipasvir is a potent, oral active inhibitor of the hepatitis C virus (HCV) NS5A with EC50 of 31 pM and 4 pM against GT1a and GT1b replicon, respectively. | ||
| M21393 | TCMDC-135051 | Others |
| TCMDC-135051 is a highly selective and potent inhibitor of the protein kinase PfCLK3 with low off-target toxicity.TCMDC-135051 prevents trophozoite to lytic transition, disrupts transcription and reduces transmission to mosquito vectors.TCMDC-135051 has antiparasitic activity (EC50=320 nM). | ||
| M22180 | DSM265 | DHODH |
| DSM265 is a long-acting inhibitor of Plasmodium falciparum dihydroorotic acid dehydrogenase (PfDHODH) with an IC50 value of 8.9 nM. In addition, DSM265 inhibits the growth of Pf3D7 with an EC50 value of 4.3 nM. | ||
| M25072 | Mipasetamab uzoptirine | TAM Receptor |
| ADCT-601 | ||
| Mipasetamab uzoptirine (ADCT-601) is an AXL-targeted antibody-drug conjugates (ADCs). Mipasetamab uzoptirine consists of a humanized anti-AXL antibody, a cleavable linker and the potent pyrrolobenzodiazepine (PBD) dimer cytotoxin SG3199. Mipasetamab uzoptirine can be used for the research of cancers. | ||
| M25141 | Iparomlimab | PD-1/PD-L1 |
| Iparomlimab is an anti-human PD-1/CD279/PDCD1 IgG4κ antibody. Iparomlimab also targets to human monoclonal PSB103 γ4-chain, disulfided with human monoclonal PSB103 κ-chain to form a dimer. Iparomlimab can be used for Oncology research. | ||
| M27683 | Purfalcamine | Parasite |
| Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage. | ||
| M27812 | Ecopipam | Dopamine Receptor |
| SCH 39166 | ||
| Ecopipam (SCH 39166) is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam can be used for the research of schizophrenia and obesity. | ||
| M28471 | UCT943 | PI3K |
| UCT943 is a next-generation Plasmodium falciparum PI4K inhibitor. UCT943 inhibits the P. vivax PI4K (PvPI4K) enzyme with an IC50 of 23 nM. | ||
| M28836 | Varespladib sodium | Phospholipase |
| LY315920 sodium | ||
| Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively. | ||
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