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Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM).
Euphol (0.01-0.3 mM; 24-72 hours) markedly inhibits T47D cells proliferation, the IC50 values of euphol treatment for 24, 48 and 72 h were 0.26, 0.22 and 0.13 mM, respectively. Euphol (0.03 mM; 48 or 72 hours) leads to cell cycle arrest by regulating expression of cell cycle-associated proteins.
| Molecular Weight | 426.72 |
| Formula | C30H50O |
| CAS Number | 514-47-6 |
| Solubility (25°C) | Ethanol 90 mg/mL DMSO 22 mg/mL |
| Storage | -20°C, protect from light |
[2] Thais Latansio de Oliveira, et al. Life Sci. Immunomodulatory and cytotoxic activities of euphol
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