Teriparatide acetate is a PHT agonist, with an IC50 of 2 nM in HEK293 cells. Teriparatide is a recombinant form of parathyroid hormone. It is an effective anabolic (i.e., bone growing) agent used to treat some forms of osteoporosis. Teriparatide (10 mg/kg or 40 mg/kg; 4 weeks) treatment significantly increased trabecular calcium by 70% and 123%, respectively, compared with the vehicle and by 73%.
| Molecular Weight | 4177.83 |
| Formula | C183H295N55O53S2 |
| CAS Number | 99294-94-7 |
| Solubility (25°C) | Soluble in water |
| Storage | -20°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] R Lindsay, et al. Osteoporos Int. Teriparatide for osteoporosis: importance of the full course
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