About 30 results found for searched term "IM-54" (0.11 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2321 | 17-DMAG (Alvespimycin) hydrochloride | HSP |
| Alvespimycin, NSC 707545 | ||
| 17-DMAG (Alvespimycin, KOS-1022, NSC 707545) hydrochloride is a potent HSP90 inhibitor with IC50 of 62 nM. | ||
| M2769 | IMD 0354 | IκB/IKK |
| IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κB pathway. | ||
| M8333 | IM-54 | Others |
| IM-54 is a cell permeable, potent and selective inhibitor of necrosis. | ||
| M2111 | Fimepinostat | HDAC |
| CUDC-907 | ||
| Fimepinostat (CUDC-907) is a potent, orally-available small molecule dual PI3K and HDAC inhibitor, with IC50 values of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10, respectively. | ||
| M2945 | Pimozide | Dopamine Receptor |
| R6238 | ||
| Pimozide is an antagonist of 6-hydroxyapatide against 6-hydroxyapatide, with Ki values of 1.4 nM, 2.5 nM and 588 nM for 6-hydroxyapatide, D3 and D1 receptors, respectively. Pimozide also has a high affinity for α1-adrenoceptor. Ki value is 39 nM. Pimozide is also an inhibitor of STAT3 and STAT5, and piperimidate triggers ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1. | ||
| M4496 | Linderalactone | Apoptosis |
| Linderalactone is an important sesquiterpene lactone isolated from Radix Linderae. Linderalactone inhibits cancer cell growth by regulating the expression of apoptosis-related proteins and inhibiting the JAK/STAT signaling pathway. Linderalactone also inhibited the proliferation of lung cancer A-549 cells with an IC50 value of 15 µM. | ||
| M4572 | Limonin | JAK |
| Limonoic acid 3,19:16,17 dilactone | ||
| Limonin is a potent inhibitor of CYP3A4 with an IC50 of 6.2 μM. Limonin inhibits HIV-1 with an EC50 of 60.0 μM. Limonin induces human colon adenocarcinoma cells apoptosis with an IC50 of 54.74 μM. Limonin, a triterpenoid rich in citrus fruits, has antiviral and anti-tumor activities. | ||
| M4849 | 7-Aminoactinomycin D | Nucleic Acid Staining |
| 7-AAD | ||
| 7-aminoactinomycin D (7-aad) can bind to DNA, and the maximum excitation/emission wavelength is 546nm/647 nm. The best excitation laser is 561nm or 488nm. It gives red fluorescence and is often used to observe the nucleus and nucleic acid. Store in freezer (-5 to -30°C) away from light. The solvent was DMSO. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M5120 | DiI | Fluorescent Dye |
| DiIC18(3) | ||
| DiI or DiIC18(3) is one of the most commonly used cell membrane fluorescent probes with a maximum excitation wavelength of 549 nm and emission wavelength of 565 nm. It shows orange-red fluorescence. Commonly used as a long-term tracer for neurons and other cells. Store at room temperature away from light. | ||
| M6352 | 5-TAMRA SE | Fluorescent Dye |
| 5-TAMRA-NHS ester; 5-Carboxytetramethylrhodamine succinimidyl ester | ||
| 5-TAMRA SE is a fluorescent dye for the labeling of amines. It forms conjugates that produce bright, pH-insensitive orange-red fluorescence (approximate excitation/emission maxima ~546/579) and exhibit good photostability. | ||
| M7690 | ML-9 | Autophagy |
| ML-9 is a potent, selective Akt kinase inhibitor that inhibits myosin light chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. It acts on MLCK, PKA and PKC with Ki values of 4, 32 and 54 μM, respectively. In addition, ML-9 induces autophagy by stimulating the formation of autophagosomes and inhibiting their degradation. | ||
| M21385 | Avdoralimab | Others |
| anti-hC5aR-32F3A6 GL;IPH-5401 | ||
| Avdoralimab (IPH5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1, and blocks C5a/C5aR1 signalling in subsets of myeloid-derived suppressor cells (MDSCs) and neutrophils. It has immunomodulating activity. | ||
| M24532 | Sifalimumab | Others |
| MEDI-545; MDX 1103 | ||
| Sifalimumab (MEDI-545) is an anti-IFNα monoclonal antibody. Sifalimumab suppresses the abnormal immune activity by binding to multiple interferon-alpha (IFNα) subtypes. Sifalimumab can be used in systemic lupus erythematosus (SLE) research. | ||
| M24871 | Bersanlimab | Integrin |
| BI-505 | ||
| Bersanlimab (BI-505) is a fully human monoclonal antibody that targets intercellular adhesion molecule-1 (ICAM-1 or CD54). Bersanlimab has anticancer effects. | ||
| M24927 | Lodapolimab | PD-1/PD-L1 |
| LY3300054 | ||
| Lodapolimab (LY3300054) is an IgGλ anti-PD-1 monoclonal antibody. | ||
| M25035 | Ezabenlimab | PD-1/PD-L1 |
| BI-754091 | ||
| Ezabenlimab (BI-754091) is an anti-PD-1 mAb with binding constant Kd value of 6 nM (CHO cells). Ezabenlimab blocks the interaction of PD-1 with PD-L1 and PD-L2. Ezabenlimab increases interferon-γ secretion in T cells, and inhibits tumor growth in vivo. | ||
| M25036 | Miptenalimab | Others |
| BI-754111 | ||
| Miptenalimab (BI-754111) is an anti-human LAG-3 antibody (KD: 88.6 nM for h LAG-3). Miptenalimab blocks the interaction of LAG-3 with its ligand MHC-II. | ||
| M25089 | Bapotulimab | Others |
| BAY-1905254 | ||
| Bapotulimab (BAY-1905254) is a fully human IgG2 antibody targeting immunoglobulin-like domain containing receptor 2 (ILDR2). Bapotulimab has antitumor and immunosuppressive effects. | ||
| M25097 | Domvanalimab | TIGIT |
| AB154 | ||
| Domvanalimab (AB154) is an anti-TIGIT humanized monoclonal antibody. Domvanalimab binds human TIGIT9 and blocks the TIGIT-CD155 interaction. Domvanalimab can be used in research of cancer. | ||
| M25160 | Clesrovimab | RSV |
| MK1654 | ||
| Clesrovimab (MK1654) is a fully human, anti-RSV fusion (RSV F) glycoprotein monoclonal antibody. Clesrovimab has the potential for the research of respiratory syncytial virus infection. | ||
| M25381 | 5-TAMRA | Fluorescent Dye |
| 5-TAMRA is a pH-insensitive orange-red fluorescence (approximate excitation/emission maxima ~546/579) with good photostability. | ||
| M25497 | (Rac)-BIO8898 | TNF Receptor |
| (Rac)-BIO8898 is a CD40-CD154 co-stimulatory interaction inhibitor. (Rac)-BIO8898 inhibits CD154 binding to CD40-Ig with an IC50 of 25 μM. | ||
| M28600 | HS-27 | HSP |
| HS-27, a fluorescently-tethered Hsp90 inhibitor, assays surface Hsp90 expression on intact tissue specimens. HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC), that binds to ectopically expressed Hsp90. HS-27 has potential use in a see-and-treat paradigm in breast cancer. | ||
| M28999 | Onfasprodil | GluR |
| Onfasprodil is negative allosteric modulator of NR2B. Onfasprodil in combination with GABA receptor regulator has the potential for the research of Alzheimer's disease (extracted from patent CN111481543A). | ||
| M29314 | PROTAC Mcl1 degrader-1 | PROTAC |
| PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC50 of 0.54 μM. | ||
| M30701 | LY 541850 | GluR |
| LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells. LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively. | ||
| M31206 | Bisindolylmaleimide VIII acetate | PKC |
| Ro 31-7549 acetate; Bis VIII acetate | ||
| Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively. | ||
| M39071 | Gefitinib impurity 1 | Metabolite/Endogenous Metabolite |
| Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM). | ||
| M45081 | Rhodamine B hydrazide | Fluorescent Dye |
| Rhodamine B hydrazide is a good sulfite probe with colorless, non-fluorescent properties, which produces fluorescence intensity dependent on sulfite concentration (5-800 ng/mL; detection limit = 1.4 ng/mL (3σ)). Sulfite reduction solubilizes oxygen and generates superoxide radicals, which bind to Rhodamine B hydrazide to form the fluorescent product Rhodamine B. This fluorescence can be enhanced by Tween 80 surfactant micelles.Rhodamine B hydrazide exhibits maximum absorption at 554 nm and maximum fluorescence emission at 574 nm. Rhodamine B hydrazide has maximum absorption at 554 nm and maximum fluorescence emission at 574 nm. | ||
| M45284 | AMG-548 dihydrochloride | p38 MAPK |
| AMG-548 dihydrochloride is an orally active, selective inhibitor of p38α (Ki=0.5 nM), slightly selective for p38β (Ki=36 nM), and >1000-fold selective for p38γ and p38δ. AMG-548 dihydrochloride also potently inhibits whole blood LPS-stimulated TNFα (IC50=3 nM). LPS-stimulated TNFα (IC50=3 nM). In addition, AMG-548 dihydrochloride inhibits Wnt signaling through direct inhibition of Casein kinase 1 isoforms δ and ε. | ||
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