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Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively. Bisindolylmaleimide VIII acetate (5 μM; 8, 12 hours) dramatically increases TRA-8-induced cell death in time-dependent and TRA-8 dose-dependent manners.
Molecular Weight | 458.51 |
Formula | C26H26N4O4 |
CAS Number | 138516-31-1 |
Form | Solid |
Solubility (25°C) | DMSO >100 mg/mL (Need ultrasonic) |
Storage | -20°C, dry, sealed |
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