Certificate of Analysis

 

Product Name: Bisindolylmaleimide VIII acetate
Catalog Number: M31206
CAS Number: 138516-31-1

Physical and Chemical Properties
Formula: C26H26N4O4
Molecular Weight: 458.51
Form: Solid
Solubility: DMSO >100 mg/mL (Need ultrasonic)
Storage: -20°C, dry, sealed
Chemical Structure: Bisindolylmaleimide VIII acetate Structure
Analytical Data
QC Standard: ≥99.0%
H-NMR: Consistent with structure
Product Information
Description: Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.