About 28 results found for searched term "IDO2-IN-1" (0.143 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M56704 | IDO1/2-IN-1 | IDO |
| IDO1/2-IN-1 is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. | ||
| M56703 | IDO1/2-IN-1 hydrochloride | IDO |
| IDO1/2-IN-1 hydrochloride is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. | ||
| M58329 | IDO2-IN-1 | IDO |
| IDO2-IN-1 is an orally active and potent Indoleamine 2,3-dioxygenase 2 (IDO2) inhibitor with an IC50 value of 112 nM. IDO2-IN-1 can be used for the research of inflammatory autoimmunity. | ||
| M2328 | Pirfenidone | TGF-beta/Smad |
| AMR69; S-7701 | ||
| Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells. Pirfenidone (AMR69) attenuates CCL2 and CCL12 production in fibrocyte cells. | ||
| M58372 | (S)-LY-3381916 | IDO |
| (S)-IDO1-IN-5 | ||
| (S)-LY-3381916 is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1. | ||
| M2825 | Lurasidone hydrochloride | 5-HT Receptor |
| SM-13496 | ||
| Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively. | ||
| M2850 | Midostaurin | PKC |
| PKC412 | ||
| Midostaurin (pkc412) is a multi-targeted kinase inhibitor, including PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 ranging from 80-500 nM. | ||
| M4578 | Oridonin | NLR |
| Isodonol；NSC-250682 | ||
| Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Oridonin (NSC-250682) also acts as an inhibitor of AKT, with IC50 values of 8.4 and 8.9 μM for AKT1 and AKT2, respectively. | ||
| M4876 | Vidofludimus | DHODH |
| SC12267, 4SC-101 | ||
| Vidofludimus (4SC-101; SC12267) is an immunosuppressant that inhibits DHODH and inhibits il-17 secretion without affecting lymphocyte proliferation. | ||
| M9933 | Tolinapant(ASTX660) | IAP |
| ASTX-660 | ||
| ASTX660 is a potent, non-peptidomimetic antagonist of cIAP1/2 and XIAP, it potently inhibited the interactions between a SMAC-derived peptide and the BIR3 domains of XIAP (BIR3-XIAP) and cIAP1 (BIR3-cIAP1) with IC50 values less than 40 and 12 nmol/L, respectively. | ||
| M6309 | IDO-IN-2 | IDO |
| IDO-IN-2 is an IDO inhibitor, with IC50 values of 0.068 μM in HeLa cell and 0.16 μM in HEK293 cell. | ||
| M10377 | Golidocitinib (AZD4205) | JAK |
| AZD-4205; Golidocitinib | ||
| Golidocitinib (AZD4205) is a novel potent and selective janus kinase 1 (JAK1) inhibitor, with IC50 value of 73 nM. | ||
| M10724 | Pridopidine | Dopamine Receptor |
| ACR16; ASP2314; FR310826 | ||
| Pridopidine is a dopamine (DA) stabilizer that acts as a low-affinity dopamine D2 receptor (D2R) antagonist. Pridopidine high affinity acts on sigma 1 receptor (S1R),Ki Values of 70 to 80 nM are approximately 100 times higher than their affinity for D2R. | ||
| M13872 | Ocaperidone | 5-HT Receptor |
| R79598 | ||
| Ocaperidone is an effective antipsychotic agent, acting as a potent 5-HT2 and dopamine D2 antagonist, and a 5-HT1A agonist, with Kis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT2, a1-adrenergic receptor, dopamine D2, histamine H1 and a2-adrenergic receptor, respectively. | ||
| M19174 | Halleridone | Keap1-Nrf2 |
| Halleridone is a natural product isolated from Halleria lucida (Scrophulariaceae), Teucrium decipiens, Phyla nodiflora and the stems of the plant Cornus walteri. Halleridone activated Nrf2-mediated HO-1 expression and inhibited Aβ1-42-overexpressed microglial BV-2 cell activation. | ||
| M29277 | Imsamotide | IDO |
| IDO194-214 | ||
| Imsamotide (IDO194-214) is a Indoleamine 2,3-Dioxygenase (IDO) peptide with sequences of DTLLKALLEIASCLEKALQVF, the IDO194-214. Imsamotide is also an immunological agent for active immunization, as well as an antineoplastic agent. | ||
| M29484 | IDO-IN-13 | IDO |
| IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an EC50 of 17 nM, extracted from patent WO2019040102A1, example 43. | ||
| M29577 | PROTAC Bcl2 degrader-1 | PROTAC |
| PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1. | ||
| M29809 | NU223612 | PROTAC |
| NU223612 is a potent PROTAC (PROTACs) that degrades indoleamine 2,3-dioxygenase 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO)) with a Kd of 640 nM. NU223612 potently degrades the IDO1 protein through CRBN-mediated proteasomal degradation. NU223612 is bound to CRBN with an affinity of 290 nM. NU223612 can cross the blood-brain barrier (BBB). | ||
| M30043 | TPCK | Serine/Threonine Protease |
| L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK | ||
| TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. TPCK is able to modify E7 protein in live keratinocytes following its addition to the culture medium. | ||
| M30210 | Verminoside | PARP |
| Verminoside is an iridoid isolated from Kigelia africana, exhibits anti-inflammatory and remarkable antioxidant activity with a radical-scavenging activity of 2.5 μg/mL. The genotoxicity of Verminoside on human lymphocytes is associated with elevated levels of PARP-1 and p53 proteins. | ||
| M30840 | SEC inhibitor KL-2 | Others |
| KL-2 | ||
| SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM. | ||
| M31179 | 12-HETE | Apoptosis |
| 12-HETE is a metabolite of arachidonic acid catalyzed by lipoxygenase (12-LOX). It is also a highly selective ligand that can be used to label mu opioid receptors in membrane and tissue sections. In addition, 12-HETE functions as an inhibitor of apoptosis. | ||
| M31272 | Thalidomide-C2-amido-C2-COOH | E3 Ligase Ligand-Linker Conjugates |
| Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase, and a linker. Thalidomide-C2-amido-C2-COOH can be used to design PROTAC CDK2/9 Degrader-1. | ||
| M31274 | NH2-C2-amido-C2-Boc | PROTAC Linker |
| NH2-C2-amido-C2-Boc is a PROTAC linker, which refers to the alkyl/ether composition. NH2-C5-NH-Boc can be used in the synthesis of a series of PROTACs, such as the PROTAC CDK2/9 Degrader-1. | ||
| M42449 | IDO1-IN-22 | IDO |
| IDO1-IN-22 is a IDO1 inhibitor (biochemical hIDO1 IC50: 67.4 nM, HeLa hIDO1 IC50: 17.6 nM). | ||
| M55411 | N-Arachidonylglycine | Metabolite/Endogenous Metabolite |
| NAGLY; NA-Gly | ||
| N-Arachidonylglycine (NA-Gly) is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration. | ||
| M55581 | PT-179 | Ligand for E3 Ligase |
| PT179 | ||
| PT-179 is an orthogonal Thalidomide (M2225) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein. | ||
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