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TPCK

Cat. No. M30043

All AbMole products are for research use only, cannot be used for human consumption.

TPCK Structure
Synonym:

L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK

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Quality Control & Documentation
Biological Activity

TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. TPCK is able to modify E7 protein in live keratinocytes following its addition to the culture medium.

Chemical Information
Molecular Weight 351.85
Formula C17H18ClNO3S
CAS Number 402-71-1
Form Solid
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jay Trivedi, et al. Biochem Biophys Res Commun. N-p-Tosyl-L-phenylalanine chloromethyl ketone (TPCK) inhibits HIV-1 by suppressing the activity of viral protease

[2] Rana Anjum, et al. FEBS Lett. TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues

[3] Z Fabian, et al. Biochem Biophys Res Commun. TPCK targets elements of mitotic spindle and induces cell cycle arrest in prometaphase

[4] Z Fabian, et al. Apoptosis. TPCK-induced apoptosis and labelling of the largest subunit of RNA polymerase II in Jurkat cells

[5] E Schmitt, et al. Biochem Cell Biol. The Bcl-xL and Bax-alpha control points: modulation of apoptosis induced by cancer chemotherapy and relation to TPCK-sensitive protease and caspase activation

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Keywords: TPCK, L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK supplier, Serine/Threonine Protease, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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