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Pridopidine

Cat. No. M10724
Pridopidine Structure
Synonym:

ACR16

Size Price Availability Quantity
25mg USD 320  USD320 In stock
50mg USD 500  USD500 In stock
100mg USD 780  USD780 In stock
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Quality Control & Documentation
Biological Activity

Pridopidine is a dopamine (DA) stabilizer that acts as a low-affinity dopamine D2 receptor (D2R) antagonist. Pridopidine high affinity acts on sigma 1 receptor (S1R),Ki Values of 70 to 80 nM are approximately 100 times higher than their affinity for D2R.

Chemical Information
Molecular Weight 281.41
Formula C15H23NO2S
CAS Number 346688-38-8
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Magdalena Jabłońska, et al. Rev Neurosci. Pridopidine in the treatment of Huntington's disease

[2] Susanna Waters, et al. J Huntingtons Dis. Pridopidine: Overview of Pharmacology and Rationale for its Use in Huntington's Disease

[3] Kathleen M Shannon. Expert Opin Investig Drugs. Pridopidine for the treatment of Huntington's disease

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Keywords: Pridopidine, ACR16 supplier, Dopamine Receptor, inhibitors, activators


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