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Pridopidine

Cat. No. M10724
Pridopidine Structure
Synonym:

ACR16

Size Price Availability Quantity
5mg USD 140  USD140 In stock
10mg USD 240  USD240 In stock
25mg USD 520  USD520 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Pridopidine is a dopamine (DA) stabilizer that acts as a low-affinity dopamine D2 receptor (D2R) antagonist. Pridopidine high affinity acts on sigma 1 receptor (S1R),Ki Values of 70 to 80 nM are approximately 100 times higher than their affinity for D2R.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 281.41
Formula C15H23NO2S
CAS Number 346688-38-8
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Magdalena Jabłońska, et al. Rev Neurosci. Pridopidine in the treatment of Huntington's disease

[2] Susanna Waters, et al. J Huntingtons Dis. Pridopidine: Overview of Pharmacology and Rationale for its Use in Huntington's Disease

[3] Kathleen M Shannon. Expert Opin Investig Drugs. Pridopidine for the treatment of Huntington's disease

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Keywords: Pridopidine, ACR16 supplier, Dopamine Receptor, inhibitors

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